抑郁症患者血清脑源性神经生长因子、P物质、白细胞介素-6水平变化及临床意义

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Abstract Objective To study the changes of serum brain-derived neurotrophic factor (BDNF), substance P (SP) and interleukin-6 (IL-6) levels in patients with depression and to analyze their clinical significance. Methods Sixty cases of patients with depression admitted to the Third Hospital of Quzhou City from March 2016 to March 2018 were recorded as the depression group, according to the severity of illness, they were divided into mild group (n = 15), moderate group (n = 29) and severe group (n = 16), and divided into duration of disease ＜5 years (n = 28) and duration of disease ≥5 years (n = 32) according to the course of disease. Another 60 healthy persons who took physical examination at the same time were recorded as healthy control group. The levels of serum BDNF, SP and IL-6 in the two groups were compared respectively, and the relationship between the level of serum BDNF, SP and IL-6 in patients was analyzed. Results The level of serum BDNF of patients in the depression group was lower than that in the healthy control group, while the levels of SP and IL-6 were higher than the healthy control group, the differences were statistically significant (P ＜ 0.05). The levels of serum BDNF in mild group, moderate group and severe group decreased gradually, while the levels of serum SP and IL-6 increased gradually, the differences were statistically significant among the there groups (P ＜ 0.05). The level of serum BDNF in patients with depression ＜5 years was higher than that in patients with depression ≥5 years, while serum SP and IL-6 levels in patients with depression ＜5 years were lower than those in patients with depression ≥5 years, the differences were statistically significant (P ＜ 0.05). Pearson correlation analysis showed that serum BDNF was negatively correlated with SP and IL-6 (r = -0.632, -0.601, all P ＜ 0.05), while SP was positively correlated with IL-6 (r = 0.676, P ＜ 0.05). Conclusion The level of serum BDNF of patients with depression is significantly decreased, while the levels of SP and IL-6 are increased. The levels of these three indexes are related to the severity and course of depression.

Key words： Depression Brain-derived neurotrophic factor Substance P Interleukin-6 Correlation

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	WANG Mei1 CHENG Tao2 YANG Kairen1 JIN Pang1 ZHOU Bo1

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WANG Mei1 CHENG Tao2 YANG Kairen1 JIN Pang1 ZHOU Bo1. Changes and clinical significance of serum levels of brain-derived neurotrophic factor, substance P and interleukin-6 in patients with depression[J]. 中国医药导报, 2019, 16(13): 95-98.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I13/95

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