维持性透析患者血管钙化的相关影响因素研究

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Abstract Objective To analyze main influencing factors of vascular calcification in maintenance dialysis patients and to provide the foundation for finding the methods to prevent vascular calcification. Methods A total of 300 maintenance dialysis patients treated in Urology Department in Liuzhou Worker′s Hospital between May 2013 and May 2017 were selected as research objects. The retrospective analysis of relevant clinical data was conducted, and all the correlated indexes of venous blood of patients on an empty stomach were measured. Dual energy X-ray absorptiometry was adopted to detect bone density, and then the calcification scores were done based on X-Ray films of lateral projection of abdomen, anteroposterior projection of hands and pelvis to determine the degree of vascular calcification. Logistic regression was used to analyze the influencing factors after grouping. Results Compared with patients with mild calcification and without calcification, patients with moderate and severe calcification had statistical differences in age, dialysis age, incidence rate of diabetes, low density lipoprotein (LDL), alkaline phosphatase (ALP) , blood calcium level after correction and femur density (P ＜ 0.05). Compared with non-diabetic patients, the incidence of VC in diabetic patients significantly increased, and the difference was statistically significant (P ＜ 0.05). Logistic regression analysis results showed that age, dialysis age, diabetes, LDL and ALP were the influencing factors of moderate and severe vascular calcification(P ＞ 0.05). Conclusion These factor, such as age, dialysis age, diabetes, LDL, ALP, blood calcium level after correction and femur density may lead to and help the development of vascular calcification of maintenance dialysis patients, among which age, dialysis age, diabetes, LDL and ALP were the influencing factors of moderate and severe vascular calcification.

Key words： Maintenance dialysis Vascular calcification Diabetes Influencing factors

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LIU Qian. Study on correlated influencing factors of vascular calcification in maintenance dialysis patients[J]. 中国医药导报, 2019, 16(13): 88-90,111.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I13/88

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