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| Advances in the relationship between FoxO1 transcription factors and liver fibrosis |
| LIAO Dan1 QIAN Bo2 XU Min1 |
1.Department of Gastroenterology, Shanghai First People′s Hospital, Nanjing Medical University, Shanghai 200080, China;
2.Department of Internal Medicine, Maternal and Child Health Hospital of Jiangsu Province, Jiangsu Province, Qidong 226200, China |
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Abstract FoxO1, as a member of the forkhead transcription factor family, can promote the expression of gluconeogenesis genes in hepatocytes, and promote the expression of ApoC-Ⅲ to form liver fibrosis caused by nonalcoholic fatty liver disease; FoxO1 regulates the expression of autophagy genes. Participate in autophagy of hepatic stellate cells to regulate liver fibrosis; FoxO1 can participate in hepatic stellate cell cycle arrest to regulate liver fibrosis; PDGF factor can regulate FoxO1 expression involved in hepatic stellate cell activation and regulate liver fibrosis; FoxO1 participates in fat differentiation of cells and myofibroblasts regulates the formation of liver fibrosis. This article will review the relationship between FoxO1 and liver fibrosis in the above aspects.
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