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| Advances in the study of transforming growth factor-β1/Smads signaling pathway in ocular surface diseases |
| WANG Yahui LI Qingsong▲ FU Zhixuan GUI Yanxiang ZHANG Bin |
| Department of Ophthalmology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China |
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Abstract The pathogenesis of ocular surface diseases is complex and diverse, among which the imbalance of ECM is one of the important causes. Transforming growth factor -β1 (TGF-β1)/Smads is involved in the development of the disease as a major signaling pathway regulating the production, outcome and metabolic balance of ECM. The relationship between this pathway and ocular surface diseases will be reviewed in this paper, which will provide a new basis for the treatment of ocular surface diseases.
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