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Research progress on the relationship between non-coding RNA and acute kidney injury |
WANG Litao1,2 LIAN Xingji3 TAN Ning2 LIU Yuanhui2 |
1.School of Medicine, South China University of Technology, Guangdong Province, Guangzhou 510006, China;
2.Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Province, Guangzhou 510100, China;
3.Department of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Province, Guangzhou 510100, China |
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Abstract Acute kidney injury (AKI) is a common serious disease characterized by rapid decline in renal function and high mortality. However, the molecular mechanism of AKI is still unclear and there is no effective treatment. Non-coding RNA (ncRNAs) participate in the pathophysiological process of AKI by regulating inflammatory response, programmed cell death and cell cycle in repair phase. Therefore, a variety of ncRNAs are not only considered as new biomarkers of AKI, but also potential therapeutic targets. This article reviews the changes, functions and potential therapeutic effects of ncRNAs in AKI.
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