高压氧科血流感染病原菌分布及耐药分析

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Abstract Objective To investigate the distributions and antibiotic resistances of pathogens isolated from the patients with bloodstream infections (BSI) in Department of Hyperbaric Oxygen (HBO), the Sixth Medical Center of PLA General Hospital (“our hospital” for short). Methods There were 266 BSI cases (male 175, female 91) in the HBO department from January 2014 to December 2018. The blood samples to be inspected were cultured with BACT/ALERT 3D system of Biomerieux, France. The 282 isolated pathogens were identified and processed antimicrobial susceptibility tests with Microflex LT mass spectrometer of Bruker Daltonics, American and VITEK 2 Compact microbiology analyzer of Biomerieux, France. The data was processed and analyzed by WHONET 5.6 software and Excel software. Results Gram-negative bacteria with the isolate rate 55.0% were the predominant BSI pathogens in the HBO Department of our hospital during the 5 years, and the proportions of Gram-positive bacteria and fungi were 40.8% and 4.2%, respectively. Klebsiella pneumoniae, total 46 strains, with the ratio of 16.3% was the major one among the Gram-negative bacteria and presented the higher resistance rate to most antimicrobial, even to the Carbapenems, which was 39.1%. Staphylococcus, total 76 strains and with the ratio of 66.1%, was the major pathogen among the Gram-positive bacteria. The sensitivity of Staphylococcus aureus and Coagulase negative staphylococcus (Cons) to Vancomycin and Tigecycline were the lowest and no resistance strains were found. Totally 12 fungi were all Candida, with the resistance rates to Flucytosine, Fluconazole, Voriconazole and Amphotericin B were all 0.0%. Conclusion To regularly surveillance the distributions and antibiotic resistances of pathogens from the BSI patients in the HBO department is very significant for clinicians to perform empiric and preemptive therapy.

Key words： Department of hyperbaric oxygen Bloodstream infections Pathogen Drug resistance rate

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	WANG Haidong ZHANG Yu YANG Yan LI Lin LI Hang

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WANG Haidong ZHANG Yu YANG Yan LI Lin LI Hang. Distributions and antibiotic resistances of bloodstream infectious pathogens in the department of hyperbaric oxygen[J]. 中国医药导报, 2019, 16(11): 161-164.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I11/161

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