椎动脉支架成形术和药物治疗椎动脉动脉粥样硬化狭窄的效果比较

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Abstract Objective To investigate the effect of vertebral artery stenting and drug therapy on vertebral artery atherosclerosis stenosis. Methods The clinical data of 80 patients with vertebral artery atherosclerotic stenosis from January 2012 to December 2017 in the First People′s Hospital of Ziyang of Sichuan Province were retrospectively analyzed. They were divided into control group (given drug treatment) and observation group (given vertebral artery stenting) according to the treatment method, 40 cases in each group. Relative cerebral blood flow (rCBF), relative mean transit time (rMTT), relative cerebral blood volume (rCBV) and relative peak time (rTTP) were observed before and after treatment in the two groups. The clinical efficacy, stroke and mortality in the two groups were observed after 6 months. Results There was no significant difference in rCBF, rMTT, rCBV and rTTP between the two groups before and after treatment (P > 0.05); there was no significant difference in rCBF, rMTT, rCBV and rTTP in the control group before and after treatment (P > 0.05); there was no significant difference in rCBV in the observation group before and after treatment (P > 0.05); after treatment, rCBF in the observation group was higher, while rMTT, rTTP were lower than before treatment, the difference were statistical significance (P > 0.05). The clinical treatment efficiency of the observation group was higher than that of the control group, the difference was statistically significant (P < 0.05). There was no significant difference in stroke and mortality between the two groups 6 months after treatment (P > 0.05). Conclusion Vertebral artery stenting can significantly improve rCBF, rMTT and rTTP in patients with vertebral artery atherosclerotic stenosis, and its clinical effect is good, which is worthy of clinical application.

Key words： Vertebral artery stenting Vertebral artery atherosclerosis stenosis Local relative cerebral blood flow Relative average transit time Relative cerebral blood volume Relative peak time

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	LI Xiaoyong1 LIN Jianmei2

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LI Xiaoyong1 LIN Jianmei2. Effert compartion of vertebral artery atherosclerotic stenosis by ISR and drug treatment[J]. 中国医药导报, 2019, 16(11): 126-129.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I11/126

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