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| Effects of procalcitonin, Hypersensitive C-reactive protein, erythrocyte sedimentation rate and S100A9 on pulmonary tuberculosis complicated with bacterial infection |
| LIU Qiuyue1 LI Qi2 LUO Baojian1 PAN Liping3 HAN Fen1▲ |
1.Department of Intensive Care Unit, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China;
2.Department of Tuberculosis, Beijing Chest Hospital Affiliated to Capital Medical University, Beijing 101149, China;
3.Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing 101149, China |
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Abstract Objective To compare the effects of procalcitonin (PCT), hypersensitive C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR) and S100A9 protein on pulmonary tuberculosis complicated by bacterial infection. Methods Form September 2017 to August 2018 in Beijing Chest Hospital Affiliated to Capital University of Medical Sciences, 132 cases were diagnosed as tuberculosis, and according to whether the pulmonary bacterial infection they were divided into bacterial infection group (62 cases) and simple tuberculosis group (70 cases), the peripheral blood plasma samples application immunofluorescence test PCT, ELISA method for determination of S100A9 level, immunoturbidimetry was used to determine hs-CRP, the ESR was determined by the Weiss method. Results The levels of PCT, S100A9 and hs-CRP in the bacterial infection group were significantly higher than those in the pure tuberculosis group (P ＜ 0.01). Multivariate analysis showed that PCT and S100A9 were independent risk factors for pulmonary tuberculosis complicated by bacterial infection. Conclusion The levels of PCT and S100A9 in pulmonary tuberculosis patients have good clinical application value in monitoring whether the patients are complicated with pulmonary bacterial infection.
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