血清肝素结合蛋白在脓毒血症患者急性肾衰竭过程中的表达与意义

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Abstract Objective To investigate the purpose of this study was to investigate the expression and significance of serum heparin binding protein (HBP) in the process of acute renal failure in patients with sepsis and to understand its clinical value. Methods From September 2014 to September 2015, 124 patients with sepsis admitted to the emergency Department of Beijing Luhe Hospital Affiliated to Capital Medical University were selected. According to the occurrence of acute renal failure, 42 patients in the acute renal failure group with sepsis (group A), 82 patients in the group without acute renal failure group with sepsis (group B), 60 patients with acute renal failure without sepsis (group C), and 60 healthy volunteers (group D) were selected as the healthy control group. Venous blood was collected in each group within 24 h after admission and after corresponding treatment, and serum HBP and serum creatinine concentrations were measured. Results Before treatment, compared with the healthy control group, the HBP level of group A and group B was significantly higher than that of group C and group D (P ＜ 0.05), while the serum HBP level of group A with acute renal failure was significantly higher than that of group B (P ＜ 0.05). After treatment, only group A showed A significant decrease in HBP level (P ＜ 0.05). Conclusion HBP can be used as a method to evaluate the occurrence of acute renal failure in patients with sepsis and to evaluate its therapeutic effect.

Key words： Sepsis Acute kidney injury Serum heparin binding protein Serum creatinine

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	LI Li′na1 CHEN Xinguang2 LYU You3▲

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LI Li′na1 CHEN Xinguang2 LYU You3▲. Expression and significance of serum heparin binding protein in acute renal failure in patients with sepsis[J]. 中国医药导报, 2019, 16(11): 109-111,141.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I11/109

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