开胃消食合剂对功能性消化不良大鼠胃动素和生长抑素的影响

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Abstract Objective To study the therapeutic effect of Kaiwei Xiaoshi Mixture on functional dyspepsia (FD) rats and its related mechanism. Methods Sixty male Wistar rats were randomly divided into blank group, model group, positive drug group, low dose of Kaiwei Xiaoshi Mixture group, middle dose of Kaiwei Xiaoshi Mixture group and high dose of Kaiwei Xiaoshi Mixture group. The blank group rats were fed normally. The rest of rats were fed with starvation and satiety disorders and tail-clipping irritation for 14 days to establish FD model. The gavage treatment lasted for 14 days. At the end of the experiment, the mental state of rats in each group was observed and the weight of rats was recorded. The gastric emptying rate and small intestinal propulsion rate of rats in each group were measured by gavage with blue dextran 2000. The contents of motilin (MTL) and somatostatin (SS) in serum and duodenal tissue were detected by enzyme-linked immunosorbent assay (ELISA). Results Compared with the blank group, the body weight of the model group decreased (P ＜ 0.01); compared with the model group, the body weight in the middle and high dose of Kaiwei Xiaoshi Mixture groups increased (P ＜ 0.05 or P ＜ 0.01). Compared with the blank group, the gastric emptying rate of the model group decreased (P ＜ 0.01); compared with the model group, the gastric emptying rate in high dose of Kaiwei Xiaoshi Mixture group increased (P ＜ 0.05). Compared with the blank group, the small intestine propulsion rate of the model group was significantly decreased (P ＜ 0.01); compared with the model group, the intestinal propulsion rate in low, middle and high dose of Kaiwei Xiaoshi Mixture groups increased, while there were no statistically significant differences (P ＞ 0.05). Compared with the blank group, the MTL content in the serum and duodenum of the model group was significantly decreased (P ＜ 0.05 or P ＜ 0.01); compared with the model group, the MTL content in serum and duodenum of high dose of Kaiwei Xiaoshi Mixture group increased (P ＜ 0.05 or P ＜ 0.01). Compared with the blank group, the SS content in the serum and duodenum of the model group was significantly increased (P ＜ 0.05); compared with the model group, the SS content in serum and duodenum of high dose of Kaiwei Xiaoshi Mixture group reduced (P ＜ 0.05). Conclusion Kaiwei Xiaoshi Mixture has the effect of treating FD and can significantly increase gastric emptying rate and small intestinal propulsion rate, and its mechanism is closely related to the improvement of gastrointestinal hormones SS and MTL secretion.

Key words： Kaiwei Xiaoshi Mixture Functional dyspepsia Motilin Somatostatin

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	WU Yuanxiang1
	2 ZHU Fangshi1 XUE Ruihua2 LIU Jian2 SHAO Changle1 MA Jinxia1 YAN Zhanpeng1

Cite this article:

WU Yuanxiang1,2 ZHU Fangshi1 XUE Ruihua2 LIU Jian2 SHAO Changle1 MA Jinxia1 YAN Zhanpeng1. Effect of Kaiwei Xiaoshi Mixture on motilin and somatostatin in rats model of functional dyspepsia[J]. 中国医药导报, 2019, 16(11): 18-22.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I11/18

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