吴茱萸+芒硝外用辅助干预用于重症胰腺炎的疗效研究

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Abstract Objective To study the influence of external adjuvant application of Fructus Evodiae plus Natrii Sulfas on the degree of systemic inflammatory response and target organ damage in patients with severe acute pancreatitis. Methods Eighty cases of patients with severe acute pancreatitis admitted to Guangdong Hospital of Traditional Chinese Medicine from February 2013 to January 2017 were collected, and the enrolled patients were divided into two groups by single blind randomized controlled method, with 40 cases in each group. The control group received conventional therapy, on basis of which, the observation group was added with external adjuvant application of Fructus Evodiae plus Natrii Sulfas. At admission, one week after treatment, the contents of serum inflammatory indexes were measured by enzyme linked immunosorbent assay (ELISA), the contents of serum liver function indexes were detected by semi automatic biochemical analyzer, the contents of intestinal mucosal barrier indexes were measured by spectrophotometer method. Results At admission, there were no significant differences in the degree of systemic inflammatory response, liver function and intestinal mucosal barrier function between the two groups (P ＞ 0.05). One week after treatment, the contents of serum interleukin-6 (IL-6), interleukin-8 (IL-6), monocyte chemoattractant protein-1 (MCP-1), alanine aminotransferase (ALT), total bilirubin (TBiL), alkaline phosphatase (AKP), lactic acid, D-amine oxidase (DAO), endotoxin of the two groups were significantly lower than those at admission, and the contents of serum IL-6, IL-8, MCP-1, ALT, TBiL, AKP, D-lactic acid, DAO, endotox of observation group were significantly lower than those of control group (P ＜ 0.05). Conclusion External adjuvant application of Fructus Evodiae plus Natrii Sulfas can alleviate the degree of systemic inflammatory response in patients with severe acute pancreatitis, and protect target organ function.

Key words： Severe acute pancreatitis Fructus Evodiae Natrii Sulfas Systemic inflammatory response Target organ damage

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	LIN Lijun ZHOU Chunjiao HE Junming LIU Ming CAI Bingqin

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LIN Lijun ZHOU Chunjiao HE Junming LIU Ming CAI Bingqin. Study on the efficacy of external adjuvant application of Fructus Evodiae plus Natrii Sulfas on severe acute pancreatitis[J]. 中国医药导报, 2017, 14(33): 147-150.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I33/147

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