养胃颗粒联合四联疗法治疗Hp阳性慢性萎缩性胃炎的临床研究

Abstract
Figure/Table
References (24)
Related Citation (3)

Download: PDF (490 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the clinical efficacy of Yangwei Granules combined with quadruple therapy in the treatment of chronic atrophic gastritis (CAG) with positive Helicobacter pylori (Hp). Methods Eighty-one cases of Hp-positive CAG admitted to Fushun Hospital of Traditional Chinese Medicine from January 2015 to January 2017 were selected, they were randomly divided into control group (40 cases) and study group (41 cases) according to the number table method. The control group was treated with quadruple therapy and the study group was treated with Yangwei Granules combined with quadruple therapy.The clinical efficacy and Hp eradication of the two groups was compared at 90 d after treatment. The levels of motilin (MLT), endothelin (ET), gastrin (GAS), pepsinogen Ⅰ (PGI), pepsinogen Ⅱ (PGⅡ), PGⅠ/PGⅡ were recorded before and 90 d after treatment, the adverse reactions during the treatment were recorded. Results 90 days after treatment, the total effective rate in the study group was significantly higher than the control group (P ＜ 0.05). The eradication rate of Hp in the study group was significantly higher than that in the control group (P ＜ 0.05). After 90 days of treatment, MLT and ET in the two groups were lower than those before treatment, and the GAS in the study group was higher than that in the control group (P ＜ 0.05), which in the study group was higher than that in the control group (P ＜ 0.05). There were no significant differences in PGⅡ between the two groups before and 90 days after treatment (P ＞ 0.05); PGⅠ, PGⅠ/PGⅡ in the two groups increased significantly after 90 days of treatment, and the study group was higher than the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P ＞ 0.05). Conclusion Yangwei Granules combined with quadruple therapy is effective in the treatment of Hp-positive CAG. It can effectively improve the level of pepsinogen and gastrointestinal hormones without increasing the incidence of adverse reactions. It has high clinical value.

Key words： Yangwei Granules Quadruple Therapy Positive Helicobacter pylori Chronic atrophic gastritis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Lele1 GENG Lei2 LIN Xurong1 DANG Hong1

Cite this article:

ZHANG Lele1 GENG Lei2 LIN Xurong1 DANG Hong1. Clinical study of Yangwei Granules combined with quadruple therapy in the treatment of chronic atrophic gastritis with positive Hp[J]. 中国医药导报, 2019, 16(8): 152-155.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I8/152

[1] 苏泽琦，陈润花，李培彩，等.慢性萎缩性胃炎证候分布规律研究现状与思考[J].北京中医药大学学报，2015，38（1）：42-45，62.
[2] Massironi S，Cavalcoli F，Zilli A，et al. Relevance of vitamin D deficiency in patients with chronic autoimmune atrophic gastritis：a prospective study [J]. BMC Gastroenterol，2018，18（1）：172.
[3] 魏玮，杨洋.慢性萎缩性胃炎诊治现状及中医药治疗优势[J].中医杂志，2016，57（1）：36-40.
[4] Yoon K，Kim N. Reversibility of Atrophic Gastritis and Intestinal Metaplasia by Eradication of Helicobacter pylori [J]. Korean J Gastroenterol，2018，72（3）：104-115.
[5] Endo K，Nakada H，Kadota Y，et al. Risk factors for atrophic gastritis in the Japanese young and middle-aged：a study using double-contrast upper gastrointestinal barium X-ray radiography [J]. Jpn J Radiol，2018，36（12）：706-711.
[6] 孔春雨，吴梅，李昭咏，等.叶酸联合气滞胃痛颗粒对Hp阳性慢性萎缩性胃炎患者血清胃泌素、sIL－2 R及免疫功能影响[J].中国生化药物杂志，2015，35（7）：101-103.
[7] 金卫利，李伟平.养胃颗粒对Hp阳性慢性糜烂性胃炎患者血清炎症因子及Hp转阴率的影响[J].中国生化药物杂志，2017，37（10）：102-103，106.
[8] 苗艳波，程宪春，孙冠鹏，等.木香养胃颗粒对大鼠慢性萎缩性胃炎治疗作用的实验研究[J].中国中医药科技，2016，23（4）：407-409.
[9] 中华医学会消化病学分会，房静远，刘文忠，等.中国慢性胃炎共识意见（2012年，上海）[J].中华消化杂志，2013， 33（1）：5-16.
[10] 郑筱萸.中药新药临床研究指导原则（试行）[M].北京：中国医药科技出版社，2002：48.
[11] 刘庭玉，庄雅，党旖旎，等.根除幽门螺杆菌联合叶酸口服3个月治疗慢性萎缩性胃炎的长期随访研究[J].中华消化杂志，2016，36（11）：734-739.
[12] Dra■ovean SC，Boeriu AM，Akabah PS，et al. Optical biopsy strategy for the assessment of atrophic gastritis，intestinal metaplasia，and dysplasia [J]. Rom J Morphol Embryol，2018，59（2）：505-512.
[13] 朱日，骆峻，朱长乐，等.慢性萎缩性胃炎伴肠化中医证型与Hp感染、COX-2、p53表达的相关性研究[J].南京中医药大学学报，2014，30（6）：520-523.
[14] 李争.慢性萎缩性胃炎发病的危险因素与临床治疗效果评价[J].中国现代医生，2018，56（7）：31-33.
[15] 吴强.芍连胃乐片治疗肝郁气滞型慢性萎缩性胃炎32例[J].西部中医药，2017，30（10）：77-78.
[16] 郭明浩，戴明，郭遂成，等.多潘立酮胶囊联合替普瑞酮对慢性萎缩性胃炎伴肠上皮化生患者的临床研究[J].中国临床药理学杂志，2018，34（2）：99-101.
[17] 龙丹，章杰，钟冬水，等.血清胃蛋白酶原与尿素14C呼气试验检测在胃癌及其癌前病变筛查中的价值[J].中国医药科学，2017，7（17）：9-11，25.
[18] 范春梅，乔金婉.胃复春片联合埃索美拉唑治疗老年慢性萎缩性胃炎的效果及对血清炎性因子的影响[J].中国医药导报，2017，14（28）：125-128.
[19] 周学俭，王香花.养胃颗粒对慢性萎缩性胃炎大鼠胃泌素、生长抑素和前列腺素E2的影响[J].浙江中医杂志，2013，48（5）：363-364.
[20] 何子彬，周骥，杨清强，等.养胃颗粒联合铝碳酸镁治疗慢性萎缩性胃炎的临床研究[J].现代药物与临床，2018， 33（4）：856-860.
[21] 蔡建明，欧阳臻，赵明，等.HPLC法同时测定参梅养胃颗粒中4种成分[J].中成药，2016，38（11）：2391-2395.
[22] 张慧君.健胃消胀合剂对慢性萎缩性胃炎模型大鼠TGF-α、COX-2 mRNA表达的影响[J].西部中医药，2017， 30（4）：9-12.
[23] 黎友隆.健脾通络汤治疗脾胃虚弱型慢性萎缩性胃炎的效果研究[J].中国医药科学，2017，7（11）：56-58.
[24] 严学义.养胃颗粒联合三联疗法对慢性胃炎伴Hp感染的疗效观察[J].浙江临床医学，2015，17（11）：1967-1968.