双歧杆菌四联活菌片联合早期肠内营养治疗重型颅脑损伤的效果

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Abstract Objective To investigate the effect of Bifidobacterium Tetravaccine Tablets combined with early enteral nutrition on severe craniocerebral injury. Methods A total of 102 patients with severe craniocerebral injury who were treated in Benxi Central Hospital of Liaoning Province from January 2016 to May 2018 were selected. The patients were randomly divided into control group (51 cases) and study group (51 cases) according to the random number table method. The control group was given early enteral nutrition treatment. The study group was treated with Bifidobacterium Tetravaccine Tablets on the basis of the control group. The nutritional status, humoral immunity and inflammatory factors of the two groups were compared before and after treatment, the complications in the two groups during treatment were recorded. Results After treatment, the levels of albumin, albumin, prealbumin and hemoglobin in the two groups were higher than those before treatment, which of the study group were higher than those of the control group (P ＜ 0.05). After treatment, the levels of immune globulin A, immune globulin G and immune globulin M in the two groups were all higher than those before treatment, which of the study group were higher than those of the control group (P ＜ 0.05). After treatment, the levels of inflammatory factors interleukin-6, C-reactive protein, tumor necrosis factor-α and white blood cell counts in the two groups were all lower than those before treatment, which of the study group were lower than those of the control group (P ＜ 0.05). The incidence of complications during treatment in the study group was significantly lower than that in the control group (P ＜ 0.05). Conclusion Bifidobacterium Tetravaccine Tablets combined with early enteral nutrition in the treament of severe craniocerebral injury can effectively improve the nutritional status of patients, enhance immunity, alleviate inflammatory reactions, and reduce the incidence of complications, which has a certain clinical value.

Key words： Bifidobacterium Tetravaccine Tablets Early enteral nutrition Severe craniocerebral injury

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	PEI Tingna1 GAO Shujie2 LI Chunmin3

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PEI Tingna1 GAO Shujie2 LI Chunmin3. Effect of Bifidobacterium Tetravaccine Tablets combined with early enteral nutrition in the treatment of severe craniocerebral injury[J]. 中国医药导报, 2019, 16(8): 148-151.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I8/148

[1] 归燕华，归承莹，金莹燕.急救护理路径在重型颅脑损伤患者中的应用[J].实用临床护理学电子杂志，2018，3（12）：74.
[2] 白海波.双歧杆菌四联活菌片联合常规用药治疗小儿非感染性腹泻疗效观察及其对血清中IL-6、IL-17表达水平的影响[J].海南医学，2015，26（8）：1212-1214.
[3] Tian Y，Du HG，Fan CP，et al. Clinical significance of percutaneous endoscopic gastrostomy for patients with severecraniocerebral injury [J]. Chin J Traumatol，2014，17（6）：341-344.
[4] 包贇，邱炳辉，李青，等.早期肠内营养预防重型颅脑损伤病人应激性溃疡的临床研究[J].肠外与肠内营养，2016， 23（3）：133-135，142.
[5] 金蓉，张艳，仲爱玲，等.优质护理结合早期肠内营养干预对重型颅脑损伤患者功能恢复的影响[J].齐齐哈尔医学院学报，2018，39（1）：113-114.
[6] 吴立强，陈建平，何念海，等.布拉酵母菌与双歧杆菌四联活菌治疗小儿轮状病毒性胃肠炎疗效比较[J].重庆医学，2015，44（31）：4349-4351，4354.
[7] 李成英.危重颅脑损伤术后应用格拉斯哥昏迷评分护理[J].航空航天医药，2010，13（4）：589.
[8] Azim A，Haider AA，Rhee P，et al. Early feeds not force feeds：Enteral nutrition in traumatic brain injury [J]. J Trauma Acute Care Surg，2016，81（3）：520-524.
[9] 王翠娥，陈祥荣，朱蓉蓉，等.鼻肠管与鼻胃管肠内营养对重型颅脑损伤患者预后和并发症、炎症反应和肠黏膜屏障功能的影响[J].中华神经医学杂志，2017，16（6）：599-603.
[10] 陈飞翔，徐超，张存海，等.重型颅脑损伤机械通气患者留置鼻肠管进行肠内营养的效果分析[J].中华危重病急救医学，2018，30（1）：57-60.
[11] 刘伟贤，龚杰，赵东，等.早期含益生菌肠内营养支持方案对重型颅脑损伤患者血清白蛋白水平、炎性细胞因子及GCS评分的影响[J].世界华人消化杂志，2018，26（13）：803-809.
[12] 何嗪，黄国栋，武艳，等.双歧杆菌四联活菌片联合头孢克肟对细菌性肠炎患者C反应蛋白、铜蓝蛋白、触珠蛋白及α1酸性糖蛋白的影响研究[J].中国生化药物杂志，2015，35（9）：109-111.
[13] 陈中俊，刘文广，左建东，等.早期肠内营养支持在重型颅脑损伤患者的应用[J].江苏医药，2016，42（4）：482-483.
[14] 韩东景，陈文芳.合生元制剂联合早期肠内营养治疗老年重型颅脑损伤后感染的疗效[J].中国老年学杂志，2015， 35（7）：1819-1821.
[15] 单宝珍，李胜保，徐柳，等.双歧杆菌四联活菌片治疗肝硬化腹泻患者的疗效及其机理探讨[J].现代消化及介入诊疗，2015，20（2）：96-98.
[16] 董俊红.双歧杆菌四联活菌片联合醒脾养儿颗粒治疗小儿功能性消化不良的临床分析[J].现代消化及介入诊疗，2015，20（3）：231-232.
[17] 李永锋，刘博.重型颅脑损伤患者围术期脑脊液免疫球蛋白和T淋巴细胞亚群水平变化的临床意义[J].中国医学前沿杂志：电子版，2015，7（11）：128-132.
[18] 马更平，康全利，陈善文，等.早期免疫营养对重型颅脑损伤患者营养状态及免疫学指标的影响[J].海南医学院学报，2015，21（4）：498-500.
[19] 李明.神经节苷酯钠辅助治疗对急性重症颅脑损伤患者神经损伤程度及细胞因子、体液免疫的影响[J].海南医学院学报，2017，23（1）：48-51.
[20] 蔡智基，刘明，刘美秋，等.重型颅脑损伤患者去骨瓣减压术后并发症与预后的相关性分析[J].中国现代医生，2017，55（2）：83-85.
[21] 李晋，赵中平，蔡奕纯，等.IL-6、Pro-BNP以及hs-CRP在颅脑损伤患者脑脊液中的表达及意义[J].中国医药科学，2017，7（3）：113-115，141.
[22] Tan M，Zhu JC，Yin HH. Enteral nutrition in patients with severe traumatic brain injury：reasons for intolerance and medical management [J]. Br J Neurosurg，2011，25（1）：2-8.
[23] 郐国虎，金胜昔，周游，等.双歧杆菌四联活菌片联合复方谷氨酰胺肠溶胶囊在重型颅脑损伤患者中的应用效果[J].实用心脑肺血管病杂志，2017，25（12）：95-98.
[24] 洪德全，吴小霞，胡勇，等.高渗盐水治疗重型颅脑损伤后颅内压与NSE的变化及临床意义[J].中国现代医生，2017，55（36）：15-18.
[25] 沈静言.三联疗法联合双歧杆菌四联活菌片治疗幽门螺杆菌感染消化性溃疡的疗效观察[J].广西医学，2018， 40（11）：1215-1216，1223.