鸦胆子油乳联合GP化疗方案对非小细胞肺癌患者疗效及免疫功能的影响

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Abstract Objective To study the effect of Brucea Javanica Oil Emulsion combined with Cisplatin (GP) chemotherapy on the curative effect and immune function of patients with non-small cell lung cancer (NSCLC). Methods From January 2017 to January 2018, in the 184th Hospital of PLA and Affiliated Hospital of Institute of Traditional Chinese Medicine of Hu'nan Province, 80 patients with NSCLC were treated with chemotherapy were selected, they were divided into observation group and control group by random grouping method, with 40 cases in each group. The control group was treated with GP chemotherapy, and the observation group was treated with Brucea Javanica Oil Emulsion on the basis of control group. The clinical effect was compared between the two groups, the immune function index (CD3+, CD4+, CD8+, CD4+/CD8+) and quality of life in the two groups before and after treatment were compared, the adverse reaction of the two groups during the treatment was observed. Results After treatment, the total effective rate of the observation group was significantly higher than the control group, the difference was statistically significant (P < 0.05). Before treatment, there was no statistically significant difference in immune function before treatment (P > 0.05), after treatment, the positive rate of CD3+ and CD4+ cells and the ratio of CD4+/CD8+ in the observation group were higher than the control group, while the positive rate of CD8+ cells was lower than the control group, the differences were statistically significant (P < 0.05). Before treatment, there was no statistically significant difference in KPS score of the two groups (P > 0.05), after treatment, the KPS score of the two groups was increased significantly, and this of the observation group was higher than the control group, the differences were statistically significant (P < 0.05). The incidence of adverse reaction of the observation group was significantly lower than that in the control group, the difference was statistically significant (P < 0.05). Conclusion Brucea Javanica Oil Emulsion combined with GP chemotherapy in the treatment of NSCLC patients has a significant short-term effect, it can improve the immune function, reduce the incidence of adverse reactions, and improve the life quality of the patients, and provide a new reference for the chemotherapy of non-small cell lung cancer.

Key words： Brucea Javanica Oil Emulsion Non-small cell lung cancer Immune function Short-term effect Life quality

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	DENG Lan1 PENG Guolin1 JIANG Mo1 JIANG Yilan2

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DENG Lan1 PENG Guolin1 JIANG Mo1 JIANG Yilan2. Effect of Brucea Javanica Oil Emulsion combined with GP chemotherapy on curative effect and immune function of patients with non-small cell lung cancer[J]. 中国医药导报, 2019, 16(8): 112-115.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I8/112

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