奥施康定联合唑来膦酸治疗晚期乳腺癌骨转移同期放化疗癌痛的效果

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Abstract Objective To observe the clinical efficacy of OxyContin combined with Zoledronic Acid in the treatment of advanced breast cancer with bone metastasis cancer pain concurrent with chemoradiation therapy. Methods From April 2017 to April 2018, in Jizhong Energy Xingtai Mining Group General Hospital, 80 patients with advanced breast cancer bone metastasis cancer pain concurrent with chemoradiation therapy were selected, according to random number table method, they were divided into control group and observation group, with 40 cases in each group. Patients in the control group were treated with OxyContin for analgesia, patients in the observation group were treated with OxyContin and Zoledronic Acid for analgesia. The pain level was evaluated by numeric rating scale (NRS), the quality of life of the two groups was evaluated by Karnofsky functional status score (KPS) and the quality of life score (QOL) of the tumor patients, the increase and decrease of OxyContin dosage and adverse reactions in the two groups were observed. Results After 28 days of treatment, the NRS scores of patients in the two groups were lower than before treatment, the KPS score and QOL score were higher than before treatment, the differences were statistically significant (P < 0.05). The NRS scores of patients in the observation group were lower than the control group, the KPS score and QOL score were higher than the control group, the differences were statistically significant (P < 0.05). The rate of OxyContin reduction of patients in the observation group was higher than control group, the difference was statistically significant (P < 0.05). The incidence of constipation of patients in the observation group was lower than control group, the difference was statistically significant (P < 0.05). Conclusion OxyContin combined with Zoledronic Acid has a definite effect in the treatment of advanced breast cancer bone metastasis cancer pain concurrent with chemoradiation therapy. It can effectively reduce the degree of cancer pain, improve the quality of life of patients, and reduce the adverse effects of the simple application of OxyContin, worthy of clinical promotion.

Key words： OxyContin Zoledronic Acid Breast cancer Bone metastasis Cancer pain

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	WU Kuo LIU Mengqi ZHAO Qingshu

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WU Kuo LIU Mengqi ZHAO Qingshu. Efficacy of OxyContin combined with Zoledronic Acid in treatment of advanced breast cancer bone metastasis cancer pain concurrent with chemoradiation therapy[J]. 中国医药导报, 2019, 16(8): 100-103.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I8/100

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