卵巢子宫内膜异位症患者BDNF、CA125水平检测及其诊断价值分析

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Abstract Objective To investigate the changes of brain-derived neurotrophic factor (BDNF) and carbohydrate antigen 125 (CA125) levels in patients with ovarian endometriosis and their diagnostic value. Methods From February 2017 to June 2018, 78 patients with ovarian endometriosis (EMs) admitted to the Department of Obstetrics and Gynecology, China National Petroleum Corporation Central Hospital ("our hospital" for short) were selected as the EMs group. A total of 50 healthy women who underwent routine physical examination in our hospital during the same period were selected as the control group. The expression of BDNF and serum CA125 levels in two groups of patients and the patients with different r-AFS pathological stages were compared. The correlations between the onset and stage of ovarian EMs and the expression of BDNF and the level of serum CA125 were analyzed. The diagnostic efficacy of BDNF, CA125 and combined detection in the diagnosis of ovarian EMs were calculated. Results The expression of BDNF and serum CA125 in patients with EMs were significantly higher than those in the control group (P < 0.05). There were significant differences in BDNF expression and serum CA125 levels between patients with different r-AFS pathological stages (P < 0.05). BDNF expression and serum CA125 levels were significantly increased with the increase of r-AFS pathological stage (P < 0.05). BDNF expression and serum CA125 levels were positively correlated with ovarian EMs and r-AFS pathological stage (P < 0.05). The sensitivity, specificity and accuracy of combined detection of BDNF and CA125 in diagnosis of ovarian EMs were 98.72%, 100.00% and 99.22% respectively, which were significantly higher than those of single detection of BDNF and CA125 (r > 0.7, P < 0.05). Conclusion The abnormal increase of BDNF expression and serum CA125 level are closely related to the occurrence and development of ovarian EMs. The combined detection of BDNF and CA125 level is helpful to the staging diagnosis and evaluation of ovarian EMs.

Key words： Ovarian endometriosis r-AFS staging Brain derived neurotrophic factor Carbohydrate antigen 125

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	LI Hongxia MENG Xianning▲ HUO Zhiping WU Ya′nan WANG Hongli HAO Yuanyuan

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LI Hongxia MENG Xianning▲ HUO Zhiping WU Ya′nan WANG Hongli HAO Yuanyuan. Detection of BDNF and CA125 levels in patients with ovarian endometriosis and analysis of their diagnostic value[J]. 中国医药导报, 2019, 16(8): 80-83.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I8/80

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