嗜神经侵袭与涎腺腺样囊性癌临床特征的相关性分析

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Abstract Objective To analyze the relationship between perineural invasion (PNI) and clinical features of salivary adenoid cystic carcinoma (SACC). Methods The clinical data of SACC patients treated in Stomatology Department of the Third People's Hospital of Chengdu from January 1995 to December 2015 were retrospectively analyzed. The clinical features of 54 cases potentially relevant to PNI were selected. Logistic model was used for multivariate factors analysis. Results Among 54 cases with SACC, there were 11 patients with PNI before operation, 8 cases in palatine gland, 2 cases in sublingual gland and 1 case in parotid gland. The results showed that there were no statistically significant differences in PNI among patients with different gender, ages, clinical stages, tumor sizes and lymphatic metastasis (P ＞ 0.05), but there were statistically significant differences in PNI among patients with different lesion location, pathological type and biological indicators (P ＜ 0.05). The postoperative recurrence rate of patients with PNI was higher than that of patients without PNI (P ＜ 0.05). Conversely, postoperative survival rate of patients with PNI was lower than that of patients without PNI (P ＜ 0.05). Logistic regression results showed that lesion location, pathological type and biological indicators were closely related with PNI (P ＜ 0.05). Conclusion Lesion location, pathological type and biological indicators can be used to determine whether patients have PNI or not before operation. PNI is an independent risk factor for prognosis of SACC, which can obviously increase the postoperative recurrence rate and reduce the postoperative survival rate. Preoperative examination of patients with PNI or not can be helpful for evaluation of the prognosis of the tumor.

Key words： Salivary adenoid cystic carcinoma Perineural invasion Clinical features

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CHEN Qi. Analysis of the relationship between perineural invasion and clinical features of salivary adenoid cystic carcinoma[J]. 中国医药导报, 2017, 14(33): 118-121.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I33/118

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