鲍曼不动杆菌抗生素耐药机制研究进展

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Abstract Acinetobacter baumannii (Ab) is an important pathogens responsible for hospital-acquired infections, it is the undoubtedly one of the most successful pathogens responsible for the patients with a defective or low immune system or the ill patients in the ICU. The mechanism of multidrug resistance of 1Ab is mainly related to the hydrolysis of ndogenous enzymes to antibiotics. The reduction of affinity of antibiotics to target caused by changes in the target of agents that under the regulate of the modified enzyme. Excretion of antibiotic mediated by over-expression of efflux pump and abnormal structure of cell wall porin. The reduction of antibiotic sensitivity mediated by membrane potential abnormality that caused by permeability defect of cytomembrane. Changes of antibiotic targets. The decrease of sensitivity of antibiotics to targets mediated by changes of cell wall composition. Drug resistance mediated by enzymes dysfunction and protein synthesis abnormality that caused by insertion or deletion of endogenous or exogenous genes. In the review, we summarize current studies that contribute to the mechanism of multidrug resistance in Ab by utilizing the mechanism of various antibiotics and the virulence factors of Ab.

Key words： Acinetobacter baumannii Hospital-acquired infections Multidrug resistant Review

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	MU Peng1 HU Fangfang2 YUAN Jun1
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MU Peng1 HU Fangfang2 YUAN Jun1,3▲. Advances in the study of the mechanism of resistance of Acinetobacter baumannii to antibiotics[J]. 中国医药导报, 2019, 16(8): 47-50.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I8/47

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