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| Comparison of ultrasound-guided radiofrequency ablation and microwave ablation for the treatment of papillary thyroid microcarcinoma |
| SHEN Ji XU Huajun XIONG Weilü |
| Departmenl of Ultrasound, Huzhou Central Hospital, Zhejiang Province, Huzhou 313000, China |
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Abstract Objective To investigate the efficacy of ultrasound guided radiofrequency ablation (RFA) in the treatment of papillary thyroid microcarcinoma (PTMC) and to analyze the effect of RFA on the stress response of the patients. Methods From March 2016 to March 2017, 97 patients with PTMC were selected in Huzhou Central Hospital of Zhejiang Province. According to different treatment methods, all subjects were divided into RFA group (observation group, n = 45) and microwave ablation group (control group, n = 52). Ultrasonic follow up was performed at 1, 3, 6 and 12 months after operation respectively, the lesion foci volume of patients was observed, and the incidence of postoperative complications, the levels of serum inflammatory factors [interleukin -6 (IL-6), tumor necrosis factor -α (TNF-α) and C reactive protein (CRP)] were compared between the two groups. Results The total incidence complications after operation in the two groups was not statistically significant (P ＞ 0.05), and no serious complications occurred. No local recurrence or cervical lymph node metastases was found during the follow-up period, ultrasound showed that the volume of ablation in the two groups were increased at 1 month after operation, afterwards, the volume of the ablation range were gradually reduced. The volume decreased significantly at 6 and 12 months after operation, compared with before operation, the difference were statistically significant (P ＜ 0.05). There was no significant difference in the volume reduction rate and volume of ablation foci between the two groups at each follow-up time point (P ＞ 0.05). Serum IL-6, TNF-α and CRP levels of the two groups were higher 24 h after surgery than before (P ＜ 0.05). The levels of serum IL-6, TNF-α and CRP levels recovered basically 72 h after surgery, with no statistically significant difference compared with that before surgery (P ＞ 0.05). There was no significant difference in the levels of serum IL-6, TNF-α and CRP levels between the two groups 24 h and 72 h after surgery (P ＞ 0.05). Conclusion Ultrasound guided RFA is an effective and safe method for the treatment of PTMC.
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