安宫牛黄丸联合丁苯酞治疗重症脑梗死的效果

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Abstract Objective To investigate the effect of Angong Niuhuang Pills combined with Butylphthalide on severe cerebral infarction. Methods From January 2015 to December 2017, 88 patients with severe cerebral infarction to the Department of Neurology of Taizhou Hospital Affiliated to Wenzhou Medical University were selected and divided into experimental group and control group according to the random number table method, with 44 patients in each group. The control group was treated with conventional western medicine comprehensive treatment, and the experimental group was treated with Angong Niuhuang Pill combined with Butylphthalide injection on the basis of conventional western medicine comprehensive treatment. The treatment duration of both groups was 14 d. Glasgow coma scale (GCS) and National Institutes of Health Stroke Scale (NIHSS) were scored before treatment, 7 d after treatment and 14 d after treatment, respectively, and serum neuron enolase (NSE) and matrix metalloproteinase-13 (mmp-13) levels were detected. Results The overall efficacy of the experimental group was better than that of the control group (P ＜ 0.05). The GCS scores of the experimental group were higher than that of the control group 7 d and 14 d after treatment (P ＜ 0.05). The NIHSS score, serum NSE level and mmp-13 level 14 d after treatment were lower than those in the control group, and the difference were statistically significant (P ＜ 0.05). Conclusion Angong Niuhuang Pill combined with Butylphthalide injection can reduce the degree of consciousness disorder in patients with severe cerebral infarction, reduce central nervous injury and neurological functional defects, and the effect is better than conventional western medicine comprehensive treatment.

Key words： Angong Niuhuang Pill Butylphthalide Severe cerebral infarction Glasgow coma index National Institutes of Health Stroke Scale Neuron enolase Matrix metalloproteinases-13

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	HU Xiaofei1 ZHU Xianhua2 ZHOU Yan1 JIN Xiaoping1

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HU Xiaofei1 ZHU Xianhua2 ZHOU Yan1 JIN Xiaoping1. Effect of Angong Niuhuang Pills combined with Butylphthalide on severe cerebral infarction[J]. 中国医药导报, 2019, 16(7): 76-79.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I7/76

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