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| Study of the interaction between polymorphisms of URAT1 gene and HUA in Uyghur |
| LI Rui1 QIN Liyan2 ZHANG Bei1 CHEN Wujin1 SUN Yuping1 |
1.School of Basic Medical Sciences, Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830011, China;
2.The Sixth Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830002, China |
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Abstract Objective To explore the interaction between human urate transporter 1 (URAT1) gene rs3825018, rs505802 and rs524023 gene polymorphisms and Uygur hyperuricemia (HUA). Methods A total of 2340 Uygur subjects who took part in physical examination in the health management center of an Affiliated Hospital in Urumqi from November 2014 to December 2016 were selected as subjects and divided into HUA group (n = 986) and control group (n = 1354) according to the level of uric acid. The body height, weight, waist and hip circumference, blood pressure and other general indicators were measured. The venous blood samples were collected after fasting for 12 hours. The biochemical indicators such as serum uric acid, creatinine, glucose, total cholesterol and triacylglycerol, and the polymorphisms of URAT1 gene rs3825018, rs505802 and rs524023 loci were detected. Results The distribution of alleles and genotype frequencies of rs3825018, rs505802 and rs524023 in URAT1 gene were not significantly different between HUA group and control group (P > 0.05). Genetic model analysis found that rs3825018, rs505802 and rs524023 were not significantly associated with Uyghur HUA in all three genetic models (95% CI across 1), regardless of age or gender. The results of the interaction showed that there was a negative interaction between the Uygur females carrying the rs505802 locus mutation in the additive model (S = -0.146, P < 0.05). Conclusion The mutations of rs3825018, rs505802 and rs524023 in URAT1 gene may not affect the susceptibility of Uygur HUA. The risk of HUA may be reduced to some extent by carrying rs505802 mutation in Uygur women.
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