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| The protective effect of Salvianolic acid on nerve function and its influence on ET-1 level in elderly patients with acute cerebral infarction |
| GAO Aimin WANG Ning REN Cuijian LIU Yonggang QI Weijing XU Yunhe |
| Department of Internal Medicine, Baoding First Central Hospital, Hebei Province, Baoding 071000, China |
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Abstract Objective To investigate the protective effect of Salvianolic acid on nerve function and its influence on ET-1 level in elderly patients with acute cerebral infarction. Methods From July to December 2016, 96 cases of elderly patients with acute cerebral infarction admitted to the First Central Hospital of Baoding City were selected as the research objects. They were randomly divided into control group and study group according to the visiting order and number 48 cases in each group. The control group was given conventional oxygen inhalation, antiplatelet aggregation, improved microcirculation and neurotrophic drugs, and the study group was treated with Salvianolic acid on the basis of conventional control group. The clinical efficacy, neurological deficit score, endothelin-1 (ET-1) level and hemorheological indexes of the two groups were observed and compared. Results After treatment, the total effective rate of the study group was 87.50%, which was significantly higher than 68.75% of the control group (P ＜ 0.05); the neurologic impairment score of the two groups decreased compared with that before treatment (P ＜ 0.05), and the degree of reduction in the study group was better than that in the control group (P ＜ 0.05); the levels of ET-1 in the two groups were lower than those before the treatment (P ＜ 0.05), and the study group was lower than that in the control group (P ＜ 0.05); the plasma viscosity, blood viscosity, hematocrit and whole blood viscosity of the two groups were lower than those before treatment (P ＜ 0.05), and the study group was significantly lower than the control group (P ＜ 0.05); no adverse reaction occurred during the treatment of the two groups. Conclusion The application of salvianolic acid in elderly patients with acute cerebral infarction can significantly improve the therapeutic effect, improve neurological function, regulate serum ET-1 level, improve the hemorheology, and the safety is high.
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[1] 江思德，唐明山，肖静，等.脑梗死急性期治疗临床研究进展[J].医学综述，2016，22（8）：1513-1515.
[2] 艾宗耀.中医药治疗急性脑梗死的临床研究概况[J].中国中医急症，2014，23（11）：2061-2063.
[3] 赵建国，高长玉，顼宝玉，等.脑梗死和脑出血中西医结合诊断标准（试行）[J].中国中西医结合杂志，2006，26（10）：948-949.
[4] 国家中医药管理局脑病急症协作组.中风病辨证诊断标准（试行）[J].北京中医药大学学报，1994，17（3）：64-66.
[5] 郑筱萸.中药新药临床研究指导原则[M].北京：中国医药科技出版社，2002.
[6] 美国国立卫生研究院脑卒中量表（NIHSS）简介[J].临床荟萃，2009，24（8）：685.
[7] 笪正，翟正平，闫福岭.急性脑梗死进展发生的相关危险因素分析[J].中国脑血管病杂志，2014，11（11）：569-575.
[8] 吴引萍，王敏.银杏达莫注射液联合复方丹参滴丸对急性脑梗死神经功能及血液流变学的影响[J].陕西中医，2015，36（9）：1114-1115.
[9] 张毅.依达拉奉对急性脑梗死患者血浆内皮素-1、一氧化氮和血清超敏C反应蛋白的影响[J].实用临床医药杂志，2016，20（19）：129-130.
[10] 李春丽，扎西草，孙燕辉.丹参川芎嗪注射液对急性脑梗死老年患者血清血管细胞间黏附分子-1、细胞间黏附分子-1、内皮素-1和一氧化氮水平的影响[J].现代中西医结合杂志，2016，25（19）：2088-2090.
[11] 李明.血清同型半胱氨酸、血浆内皮素-1、B型利钠肽及D-二聚体联合检测对急性脑梗死的诊断价值[J].实用临床医药杂志，2015，19（1）：23-25.
[12] D′Esterre CD，Aviv RI，Morrison L，et al. Acute Multi-modal Neuroimaging in a Porcine Model of Endothelin-1-Induced Cerebral Ischemia：Defining the Acute Infarct Core [J]. Transl Stroke Res，2015，6（3）：234-241.
[13] Zhang Q，Zhang L，Yang X，et al. The effects of exercise preconditioning on cerebral blood flow change and endothelin-1 expression after cerebral ischemia in rats [J]. J Stroke Cerebrovasc Dis，2014，23（6）：1696-1702.
[14] Kolettis TM. Ventricular tachyarrhythmias during acute myocardial infarction：the role of endothelin-1 [J]. Life Sci，2014，118（2）：136.
[15] Okazaki T，Yamamoto Y，Yoda K，et al. The ratio of d-dimer to brain natriuretic peptide may help to differentiate between cerebral infarction with and without acute aortic dissection [J]. J Neurol Sci，2014，340（1/2）：133.
[16] 袁凤云，刘玉梅，孙科远，等.丹参多酚酸盐对脑梗死患者脑血流动力学的影响分析[J].中国煤炭工业医学杂志，2015，18（6）：895-898.
[17] 王珲，王琴，戚妹，等.丹参多酚酸盐对脑梗塞患者脑血流动力学的影响[J].海南医学，2015，26（6）：794-796.
[18] 苏占清，张毅欣，杨宁，等.急性脑梗死中医病机初探[J].辽宁中医药大学学报，2014，16（3）：175-177.
[19] 冯容，陈永斌.活血化瘀疗法治疗急性脑梗死研究概述[J].中国中医急症，2016，25（4）：668-671.
[20] 贺亚龙，高焱，郭晓贤.丹参多酚酸治疗急性脑梗死的临床研究[J].现代药物与临床，2016，31（9）：1354-1359.
[21] 王玉莲.丹参多酚酸盐、压力袜联合低分子肝素钙预防妇科术后下肢深静脉血栓的临床研究[J].中国医药科学，2017，7（7）：240-242. |
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