补肝益肾方治疗绝经后骨质疏松症的临床观察

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Abstract Objective To explore the clinical effects of BuganYishen prescription in the treatment of postmenopausal osteoporosis. Methods A total of 92 cases of patients with postmenopausal osteoporosis treated in Baoji Hospital of Traditional Chinese Medicine from February 2015 to August 2016 were selected as research objects and divided into observation group and control group by random number table, with 46 cases in each group. The control group was given Alfacalcidol Soft Capsules combined with Vitamin D chewable tablets orally and the observation group was added with BuganYishen prescription on the basis of control group. The two groups were all treated for 2 courses totally, 3 months as a course. The clinical effects, the scores of visual analogue scale(VAS), bone mineral density, levels of related biochemical indexes and the incidence of adverse reactions in the two groups before and after treatment were compared. Results After treatment for 6 months, the total clinical effective rate in the observation group(95.7%) was significantly higher than that of control group(82.6%), with statistically significant difference(P ＜ 0.05). After treatment for 3 months, the VAS scores in the two groups were all lower than those of before treatment(P < 0.05), while there was no significant difference between the two groups (P ＞ 0.05). After treatment for 6 months, the VAS scores in the observation group were significantly lower than those of after treatment for 3 months and those of control group at the same stage(P ＜ 0.05). After treatment for 3 months, the bone mineral density in the two groups was all significantly higher than those before treatment(P ＜ 0.05). After treatment for 6 months, the bone mineral density in the two groups was significantly higher than those after treatment for 3 months, and that in observation group was significantly higher than that of control group (P ＜ 0.05). After treatment for 3 months, the levels of alkaline phosphatase in the two groups were lower than those of before treatment, and the levels of blood calcium, estradiol, activated Vitamin D3 were all higher than those of before treatment(P ＜ 0.05). After treatment for 6 months, the indexes above in the two groups were all better than those after treatment for 3 months, and those in the observation group was much better than those of control group(P ＜ 0.05). Conclusion BuganYishen prescription on the basis of conventional western medicine in the treatment of postmenopausal osteoporosis can obviously improve the clinical efficacy, increase bone mineral density, relieve pain and the safety is good. It is worthy of clinical promotion.

Key words： BuganYishen prescription Postmenopausal osteoporosis Effect

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	FU Jiangtao1 PENG Ye2 HUANG Yonghong1▲ LEI Liang1

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FU Jiangtao1 PENG Ye2 HUANG Yonghong1▲ LEI Liang1. Clinical observation of BuganYishen prescription in the treatment of postmenopausal osteoporosis[J]. 中国医药导报, 2017, 14(33): 86-89,93.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I33/86

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