血液灌流联合血液透析对维持性血液透析所致心脏瓣膜钙化的影响

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Abstract Objective To investigate the effects of the two methods of hemoperfusion combined with hemodialysis and hemodiafiltration for the cardiac valve calcification caused by maintenance hemodialysis. Methods Sixty patients with cardiac valve calcification underwent hemodialysis because of chronic renal failure treated in the Third Hospital of Shijiazhuang City from April 2014 to May 2016 were selected and divided into group A and B by random number table method, with 30 cases in each group. Group A was taken hemoperfusion combined with hemodialysis therapy, group B was taken hemodiafiltration, both groups were treated for 6 months. The levels of fetuin-A, high-sensitivity C-reactive protein (hs-CRP), intact parathyroid hormone (iPTH) of fasting venous blood, and the improvement of blood calcium, serum phosphate, β2-microglobulin (β2-MG) before and after treatment between the two groups were compared, and the occurrence of adverse reactions of the two groups during treatment was recorded. Results After treatment, the levels of fetuin-A in the two groups were all higher than those before treatment, which of group A was higher than that of group B, the differences were all statistically significant (P ＜ 0.05); in addition, the levels of hs-CRP, iPTH, serum phosphorus and β2-MG in the two groups were all significantly lower than those before treatment, and the indexes above in group A were all significantly lower than those of group B, the differences were all statistically significant (P ＜ 0.05); after treatment, the levels of serum calcium in the two groups were all higher than those before treatment, while group A was significantly lower than that of group B, the differences were all statistically significant (P ＜ 0.05). The total incidence of clinical adverse reactions of group A was significantly lower than that of group B, the difference was all statistically significant (P ＜ 0.05). Conclusion The effects of hemoperfusion combined with hemodialysis for preventing and controlling cardiac valve calcification caused by maintenance hemodialysis are better than that of hemodiafiltration.

Key words： Heart valve calcification Hemodiafiltration Hemoperfusion Hemodialysis Fetuin-A

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	SONG Juxiang SONG Pei MA Hui

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SONG Juxiang SONG Pei MA Hui. Effects of hemoperfusion combined with hemodialysis on cardiac valve calcification caused by maintenance hemodialysis[J]. 中国医药导报, 2017, 14(33): 82-85.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I33/82

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