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| Research progress on the protective mechanism of curcumin on renal ischemia reperfusion injury |
| ZHOU Xiaoyuan1 RONG Song2 TIAN Mei1▲ |
1.Department of Rheumatology, Affiliated Hospital of Zunyi Medical College, Guizhou Province, Zunyi 563000, China;
2.Gottfried Wilhelm Leibniz Universit?覿t, Hannover 30167, Germany |
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Abstract Curcumin is a yellow acid phenolic substance extracted from Rhizoma Curcumae longae and widely used in the food industry. The kidney acts as an endocrine organ and is also a high perfusion organ, particularly sensitive to ischemia and reperfusion. When the kidney develops ischemia-reperfusion, a large amount of reactive oxygen species is produced in the later stage of ischemia-reperfusion, which causes the kidney to be in a state of high oxidative stress and triggers a series of harmful cellular reactions, leading to inflammation, apoptosis and acute kidney failure, and even can cause damage to other organs. Curcumin can up-regulate the expression of APPL1, inhibit the Akt phosphorylation pathway, inhibit the activated INOS/NO/CGMP/PKG signaling pathway, alleviate oxidative stress, inhibit inflammatory cell infiltration, up-regulate HO-1, and inhibit NF-κB activity, reduce the incidence of vasoactive substances and reduce renal damage caused by renal ischemia and reperfusion. Therefore, curcumin can be used as a new treatment method for renal ischemia-reperfusion.
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