类风湿关节炎患者血清25羟维生素D水平及相关因素分析

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Abstract Objective To investigate serum 25-hydroxyvitamin D levels in patients with rheumatoid arthritis and its related factors. Methods Eighty-two cases of patients with rheumatoid arthritis and 82 cases of healthy controls were collected from Bozhou People′s Hospital from March to December 2017, the serum 25-hydroxyvitamin D level was measured, and the general characteristics, body mass index, sun exposure time, rheumatoid factor, cyclic citrullinated peptide antibodies, antinuclear antibodies, calcium, disease activity score (DAS28), tender joint count and swollen joint count were collected. Results The serum 25-hydroxyvitamin D level insufficiency and deficiency was detected in 97.6% of rheumatoid arthritis patients. The serum 25-hydroxyvitamin D concentration in rheumatoid arthritis patients were lower than that in healthy control (P ＜ 0.01). Patients with rheumatoid arthritis with a course of less than 2 years had a higher level of 25-hydroxyvitamin D than patients with a course of more than 2 years (P ＜ 0.05). Among patients with rheumatoid arthritis, 25-hydroxyvitamin D levels in male were significantly higher than in female (P ＜ 0.05). In rheumatoid arthritis patients, serum 25-hydroxyvitamin D level was significantly associated with female (r = -0.291, P ＜ 0.01), average sun exposure time (r = 0.237, P ＜ 0.05), course (r = -0.322, P ＜ 0.01), calcium level (r = 0.300, P ＜ 0.01), tender joint count (r = -0.348, P ＜ 0.01), swollen joint count (r = -0.238, P ＜ 0.05) and DAS28 (r = -0.258，P ＜ 0.05). Conclusion 25-hydroxyvitamin D insufficiency and deficiency is quite common in patients with rheumatoid arthritis. Female, average daily sun exposure time less than 30 minutes, longer course, hypocalcemia, higher DAS28, more tender joint count and swollen joint count might be the predictors.

Key words： Rheumatoid arthritis Vitamin D Disease activity Related factor

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	ZHANG Yuhui1 SONG Weimin2 SUN Li1 MA Qin1 LI Xiaojun1 DING Xiang1 SHI Guixiu3

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ZHANG Yuhui1 SONG Weimin2 SUN Li1 MA Qin1 LI Xiaojun1 DING Xiang1 SHI Guixiu3. Analysis of serum 25-hydroxyvitamin D levels in patients with rheumatoid arthritis and its related factors[J]. 中国医药导报, 2019, 16(5): 142-145.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I5/142

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