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| Relationship between serum homocysteine, C-reactive protein and carotid arteries atherosclerosis in patients with type 2 diabetes mellitus complicated with cerebral infarction |
| YANG Ping1 LIAO Ping2 WU Wenjuan1 |
1.Department of Neurology, the Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi Zhuang Autonomous Region, Liuzhou 545006, China;
2.Department of Endocrine Metabolism, the Second Affiliated Hospital of Guangxi University of Science and Technology, Guangxi Zhuang Autonomous Region, Liuzhou 545006, China |
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Abstract Objective To investigate the relationship between serum homocysteine (Hcy), C-reactive protein (CRP) and carotid atherosclerosis in patients with type 2 diabetes mellitus complicated with cerebral infarction. Methods A total of 100 patients with type 2 diabetes mellitus complicated with cerebral infarction admitted to the Second Affiliated Hospital of Guangxi University of Science and Technology (“our hospital” for short) from January 2015 to January 2018 were included in the diabetes mellitus complicated with cerebral infarction group, and 100 patients with simple type 2 diabetes treated in our hospital during the same period were included in the simple diabetes group, and another 50 healthy individuals who underwent physical examination in our hospital during the same period were selected as the control group. Hcy, CRP, carotid intima-media thickness (IMT), fasting plasma glucose (FPG) and 2 h postprandial plasma glucose (2 h PBG) were measured and compared in each group. The correlation among Hcy, CRP and IMT, FPG and 2 h PBG was analyzed. Results There was a significant difference in Hcy, CRP, IMT, FPG and 2 h PBG between the diabetes mellitus complicated with cerebral infarction group and the simple diabetes group (P ＜ 0.05), and all the indices of the two groups were higher than those in the control group (P ＜ 0.05). In the diabetes mellitus complicated with cerebral infarction group, Hcy, CRP, FPG and 2 h PBG increased as the increase of IMT, and the difference was statistically significant (P ＜ 0.05). After intensive insulin therapy, the levels of Hcy, CRP, IMT, FPG and 2 h PBG in diabetes mellitus complicated with cerebral infarction group were significantly lower than those before treatment (P ＜ 0.05). Pearson correlation analysis result showed that Hcy and CRP had positive correlation with IMT, FPG and 2 h PBG (P ＜ 0.05). Conclusion The severity of carotid arteries atherosclerosis plaque in patients with type 2 diabetes mellitus complicated with cerebral infarction is higher than that of patients with simple diabetes, and the level of serum Hcy and CRP is positively correlated with the degree of carotid arteries atherosclerosis, which may be involved in the development process of carotid arteries atherosclerosis.
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