全胸腔镜食管癌根治术对食管癌患者炎性反应及应激反应的影响

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Abstract Objective To investigate the effect of total thoracic esophageal cancer radical surgery on inflammatory response and stress response in patients with esophageal cancer. Methods Eighty-four patients with esophageal cancer admitted to Hainan General Hospital from January 2014 to January 2018 were selected and divided into control group (n = 42) and research group (n = 42) according to the randon number table method. The control group was treated with open thoracic esophageal cancer radical surgery, the study group was treated with total thoracic esophageal cancer radical surgery. The clinical indexes of the two groups were compared. The inflammatory reaction indicators [interleukin-6 (IL-6), IL-10, tumor necrosis factor-alpha (TNF-alpha)], stress response indicators [C-reactive protein (CRP), serum free triiodothyronine (FT3), free thyroxine (FT4) and cortisol] were observed before and one week after the operation. The postoperative complication of the two groups were observed. Results The operation time, intraoperative blood loss, postoperative drainage and hospitalization time in the study group were lower than those in the control group (P < 0.05); there was no significant difference in the number of lymph nodes between the two groups (P > 0.05). The levels of IL-6, IL-10 and TNF-α were higher in the control group than in the study group one week after operation (P < 0.05). The levels of CRP, FT3, FT4 and cortisol were higher in the two groups one week after operation (P < 0.05), but there was no significant difference between the two groups (P > 0.05). There was no significant difference in the incidence of complications between the two groups (P > 0.05). Conclusion Compared with open radical esophageal cancer, radical thoracoscopic radical esophagectomy can significantly reduce the inflammatory reaction in patients with esophageal cancer, and has no significant effect on the body′s stress response and postoperative complications.

Key words： Total thoracic esophageal cancer radical surgery Open thoracic esophageal cancer radical surgery Inflammation reaction Stress response Effect

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	HUANG Xiuming CHEN Xianshan CHEN Fengxia

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HUANG Xiuming CHEN Xianshan CHEN Fengxia. Effect of total thoracic esophageal cancer radical surgery on inflammatory reaction and stress response in patients with esophageal cancer[J]. 中国医药导报, 2019, 16(5): 104-107.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I5/104

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