唑来膦酸联合同期放化疗治疗晚期乳腺癌骨转移的临床效果

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Abstract Objective To investigate clinical effect of Zoledronic acid combined with concurrent chemoradiotherapy in the treatment of bone metastasis of advanced breast cancer. Methods From January 2016 to January 2018, 107 patients with bone metastasis of advanced breast cancer who were treated in the Jizhong Energy General Hospital of Xingtai Mining Group were selected, and they were divided into observation group (n = 53) and control group (n = 54) according to the treatment plan finally. The observation group was treated with Zoledronic acid combined with concurrent chemoradiotherapy, while the control group was treated with chemoradiotherapy. The therapeutic effect, visual analogue (VAS) score and adverse reactions of the two groups were observed, and serum calcium and vascular endothelial growth factor (VEGF) levels were detected before and after treatment. Results The curative effect of the observation group was better than that of the control group (P ＜ 0.05), there was no significant difference in VAS score between the observation group and the control group before treatment (P ＞ 0.05). The VAS score of the observation group and the control group after treatment were lower those that before treatment (P ＜ 0.05), the score of VAS in the observation group after treatment was significantly lower than that in the control group after treatment (P ＜ 0.05). There was no significant difference in serum calcium and VEGF between the observation group and the control group before treatment (P ＞ 0.05), the serum calcium and VEGF in the observation group and the control group after treatment were lower than those before treatment (P ＜ 0.05). The serum calcium and VEGF in the observation group after treatment were significantly lower than those in the control group after treatment (P ＜ 0.05), there was no significant difference in the incidence of adverse reactions between the observation group and the control group (P ＞ 0.05). Conclusion Zoledronic acid combined with concurrent chemoradiotherapy in the treatment of advanced breast cancer has good clinical effect, and is worthy of clinical application.

Key words： Zoledronic acid Concurrent chemoradiotherapy Advanced breast cancer Bone metastasis Clinical effect

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	WU Kuo LIU Mengqi▲ ZHAO Qinshu

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WU Kuo LIU Mengqi▲ ZHAO Qinshu. Clinical effect of Zoledronic acid combined with concurrent chemoradiotherapy in the treatment of bone metastasis of advanced breast cancer[J]. 中国医药导报, 2019, 16(5): 96-99.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I5/96

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