呼吸道病毒感染对支气管哮喘患儿Th1/Th2细胞因子平衡的影响

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Abstract Objective To investigate the effect of respiratory viral infection on Th1/Th2 cytokines balance in children with bronchial asthma. Methods From March 2016 to February 2018, in Haikou Women′s and Children′s Hospital, 153 children with bronchial asthma were selected, and another 69 healthy children at the same period were selected as the control. The respiratory viral infection types of children with bronchial asthma were statistically analyzed, and the ratio of Th1, Th2 and Th1/Th2 in peripheral blood of children, airway function [forced expiratory volume at 1 second (FEV1), and forced vital capacity (FVC), peak expiratory flow rate (PEFR) and FEV1/FVC] and blood gas index [blood oxygen partial pressure (PaO2) and partial pressure of carbon dioxide (PaCO2)] of the children were compared. In addition, the correlation among the ratio of Th1, Th2 and Th1/Th2 in peripheral blood and airway function and blood gas index in children with bronchial asthma was analyzed. Results The positive rate of respiratory viral infection in children with bronchial asthma was 66.67% (102/153), there were 21 cases of adenovirus (AV), 27 cases of influenza virus (IFV) group 24 cases of parainfluenza virus (PIV), 30 cases of respiratory syncytial virus (RSV). Th1, Th1/Th2, FEV1, FVC, PEFR, FEV1/FVC and PaO2 of children with bronchial asthma were significantly lower than healthy children (P < 0.05), Th2, PaCO2 were significantly higher than healthy children (P < 0.05); Th1, Th1/Th2 in IFV children and RSV children were significantly lower than simple asthma children (P < 0.05), Th2 was significantly higher than simple asthma children (P < 0.05). The FEV1, FVC, PEFR, FEV1/FVC and PaO2 in children with bronchial asthma complicated with respiratory virus infection were significantly lower than simple asthma children (P < 0.05), PaCO2 was significantly higher than simple asthma children (P < 0.05). Th1, Th1/Th2 was positively correlated with FEV1, PEFR, FEV1/FVC and PaO2 (P < 0.05), but negatively correlated with PaCO2 (P < 0.05); Th2 was positively correlated with PaCO2 (P < 0.05), Th2 was negatively correlated with PEFR, FEV1/FVC and PaO2 (P < 0.05). Conclusion Respiratory virus infection affects Th1/Th2 cytokines balance in children with bronchial asthma, it inhibits Th1 cell function and activates Th2 cell function, PSV and IFV have more obvious effect among them.

Key words： Respiratory virus infection Bronchial asthma T helper cell Balance

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	WANG Kaimei1 LIN Zhixiong1 HU Xiangying1 ZHENG Guangqiang1 QIU Wenhai2

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WANG Kaimei1 LIN Zhixiong1 HU Xiangying1 ZHENG Guangqiang1 QIU Wenhai2. Effect of respiratory viral infection on Th1/Th2 cytokines balance in children with bronchial asthma[J]. 中国医药导报, 2019, 16(5): 76-79.

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