急性脑梗死患者血清ox-LDL、Lp-PLA2水平变化及临床意义

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Abstract Objective To observe the changes and significance of lipoprotein-associated phospholipase A2 (Lp-PLA2) and oxidized low density lipoprotein (ox-LDL) in patients with acute cerebral infarction (ACI). Methods One hundred and twenty-three patients with initial ACI admitted in Taizhou Enze Medical Center (Group) Enze Hospital in Zhejiang Province from January 2015 to January 2018 were selected as the observation group, and 120 cases of healthy volunteers were selected as the control group. The levels of Lp-PLA2 and ox-LDL were detected immediately after admission and at 12, 24, 72 hours after admission. According to the severity of cerebral infarction, the patients in the observation group were divided into severe cerebral infarction group (n = 34), moderate cerebral infarction group (n = 52) and mild cerebral infarction group (n = 37). The serum levels of Lp-PLA2 and ox-LDL were compared among the three groups. According to different infarct size, the patients in the observation group were divided into large infarction group (n = 38), middle infarction group (n = 49) and small infarction group (n = 36). The changes of Lp-PLA2 and ox-LDL level were compared among the three groups. Results The serum levels of Lp-PLA2 and ox-LDL in the observation group were significantly higher than those in the control group at admission and 12, 24, 72 hours after admission, the differences were statistically significant (P ＜ 0.05). In addition, the serum Lp-PLA2 and ox-LDL levels in the observation group increased first and then decreased with the increase of admission time. The levels of Lp-PLA2 and ox-LDL in severe cerebral infarction group were higher than those in moderate and mild cerebral infarction group (P ＜ 0.05), and that in moderate infarction group was higher than that in mild cerebral infarction group (P ＜ 0.05). The levels of Lp-PLA2 and ox-LDL in the large infarction group were higher than those in the middle and small infarction group (P ＜ 0.05), and that in middle infarction group was higher than that in small infarction group (P ＜ 0.05). Conclusion The levels of serum Lp-PLA2 and ox-LDL are significantly increased in patients with ACI, which can reflect the severity of the disease to a certain extent. They can be used as serum markers, which is of positive significance in evaluating the condition and prognosis of ACI.

Key words： Acute cerebral infarction Lipoprotein-associated phospholipase A2 Oxidized low density lipoprotein Prognosis

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	HONG Weijun1 HUANG Qin2

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HONG Weijun1 HUANG Qin2. The changes and significance of serum Lp-PLA2 and ox-LDL in patients with acute cerebral infarction[J]. 中国医药导报, 2019, 16(5): 72-75.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I5/72

[1] 詹青，王丽晶.急性缺血性脑卒中早期康复的时机与策略[J].神经病学与康复学杂志，2016，12（1）：1-7.
[2] 王陇德，王金环，彭斌，等.《中国脑卒中防治报告2016》概要[J].中国脑血管病杂志，2017，14（4）：217-225.
[3] 繆朝玉.脑卒中治疗靶点和药物研究[J].中国药理学与毒理学杂志，2016，30（12）：1264-1273.
[4] 郑晓红，何丽艳，陈薇，等.脂蛋白相关磷脂酶A2与急性脑梗死相关性研究[J].汕头大学医学院学报，2016，29（2）：96-99.
[5] 舒伯辉，曹春艳，张灿飞，等.血清氧化型低密度脂蛋白水平与大动脉粥样硬化性脑梗死患者中国缺血性卒中亚型分型和神经功能缺损程度的相关性研究[J].实用心脑肺血管病杂志，2018，26（3）：27-30.
[6] 陈海云，何超明.血清ox-LDL、Lp-PLA2水平与缺血性脑卒中患者动脉粥样硬化及神经功能缺损的相关性研究[J].卒中与神经疾病，2017，24（6）：504-509.
[7] 中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2010[J].中华神经科杂志，2010，43（2）：16-19.
[8] Kwah LK，Diong J. National Institutes of Health Stroke Scale（NIHSS）[J]. J Physiother，2014，60（1）：61.
[9] 熊燕华，张大庆.《脂蛋白相关磷脂酶A2临床应用中国专家建议》解读[J].中国医药导刊，2018，20（3）：139-146.
[10] 夏文翠，胡中扬，宋治.脂蛋白相关磷脂酶A2与缺血性脑卒中相关性的Meta分析[J].中南大学学报：医学版，2017，42（2）：208-215.
[11] 沈华，马明洲，张铮，等.脂蛋白相关磷脂酶A2对危重症心脑血管病患者预后的评估价值[J].内科急危重症杂志，2018，24（1）：58-60.
[12] 王智军，白蓉.血清脂蛋白相关磷脂酶A2与动脉粥样硬化性脑梗死的相关性分析[J].中国实用神经疾病杂志，2017，20（2）：22-25.
[13] 王惠，马先军，董万利，等.脂蛋白相关磷脂酶A2对大动脉粥样硬化型脑梗死病情进展的预测价值[J].脑与神经疾病杂志，2017，25（7）：407-411.
[14] Yang Y，Xue T，Zhu J，et al. Serum lipoprotein-associated phospholipase A2 predicts the formation of carotid artery plaque and its vulnerability in anterior circulation cerebral infarction [J]. Clin Neurol Neurosurg，2017，160（15）：40-45.
[15] Delgado P，Chacon P，Penalba A，et al. Temporal profile and prognostic value of LP-PLA2 mass and activity in the acute stroke setting [J]. Atherosclerosis，2012，220（2）：532-536.
[16] 王春阳.氧化型低密度脂蛋白与动脉粥样硬化进展[J].中西医结合心血管病杂志，2017，5（29）：34-35.
[17] 马志远，陈艳，陈庞河，等.急性脑梗死患者氧化低密度脂蛋白、hs-CRP、Hcy、D-二聚体水平及其临床意义[J].内科，2017，12（2）：171-174.
[18] 陈杨，冯加纯.缺血性卒中生化标志物的研究进展[J].中国脑血管病杂志，2018，15（3）：157-162.
[19] 戚志强，董海蓉，周红，等.急性脑梗死患者病情与血清Lp-PLA2水平的相关性[J].江苏医药，2017，43（14）：1013-1016.
[20] 黄蕊，黄永，刘兴钊，等.血清ox-LDL、AIP水平与急性脑梗死患者颈动脉内膜中层厚度的关系[J].中国医药导报，2018，159（4）：61-64.
[21] 王特，刘运海.Ox-LDL与动脉粥样硬化的研究进展[J].中国医药指南，2011，9（29）：231-233.
[22] 朴海，金永华.急性脑梗死患者血浆Lp-PLA2和hs-CRP水平及意义[J].哈尔滨医科大学学报，2012，46（3）：266-270.
[23] Trpkovic A，Resanovic I，Stanimirovic J，et al. Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases [J]. Crit Rev Clin Lab Sci，2015，52（2）：70-85.