动脉粥样硬化、急性冠脉综合征患者血清HDL2b水平变化及临床意义

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Abstract Objective To study the changes and clinical significance of serum high density lipoprotein 2b (HDL2b) in patients with atherosclerosis and acute coronary syndromes. Methods A total of 81 cases with atherosclerosis admitted to Zhejiang Provincial General Hospital of Chinese People′s Armed Police Force (“our hospital” for short) from February 2016 to December 2017 were selected as group A, another 175 cases with acute coronary syndrome admitted to our hospital in the same period were selected as group B, and then 100 healthy individuals that performed physical examination in our hospital in the same period were taken as control group. Serum HDL2b level and serum lipid level were compared among the three groups, and their correlation was analyzed. Serum HDL2b levels were compared in patients with acute coronary syndrome of different degrees coronary artery disease. Results The serum level of HDL2b in group A and B were lower than that in the control group, and the serum level of HDL2b in group B was lower than that in group A, the differences were statistically significant (P ＜ 0.05). High density lipoprotein cholesterol (HDL-C) level in group A and B were lower than that in the control group, and HDL-C level in group B was lower than that in group A, and the differences were statistically significant (P ＜ 0.05). According to the Pearson correlation analysis results, there was a positive correlation between serum HDL2b and HDL-C in group B (P ＜ 0.05). There was a decreasing tendency of HDL2b level in the single vessel lesion group, double vessels lesion group, multiple vessels lesion group orderly. Single factor analysis of variance could prompt that the differences among the three groups were statistically significant (P ＜ 0.05). Conclusion Serum HDL2b levels is low expressed in patients with atherosclerosis and acute coronary syndrome. In clinic, the relationship between metabolic disorder and disease can be determined by detecting serum HDL2b level, and it can provide guidance for clinical treatment therapy.

Key words： Atherosclerosis Acute coronary syndrome High density lipoprotein 2b Microfluidic chip technology

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	LUO Jianhua WANG Chao YUE Yuguo

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LUO Jianhua WANG Chao YUE Yuguo. Serum HDL2b level changes and clinical significance in patients with atherosclerosis and acute coronary syndrome[J]. 中国医药导报, 2019, 16(5): 55-58.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I5/55

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