甲亢源性心房颤动与心房交感神经重构相关的发病机制研究

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Abstract Objective To study the pathogenesis of hyperthyroidism-induced atrial fibrillation and atrial sympathetic nerve remodeling. Methods According to random number table method, 50 adult healthy Japanese big ear rabbits were divided into two month administration group (n = 20), four month administration group (n = 20) and control group (n = 10). The two month administration group received intraperitoneal injection of thyroxine 50 μg/kg daily for 2 months, the four month administration group received intraperitoneal injection of thyroxine 50 μg/kg daily for 4 months, and the control group received intraperitoneal injection of equal dose of normal saline for 4 months. Animal models of hyperthyroidism and atrial fibrillation vulnerability were prepared. The basic data, left atrial effective refractory period (LAERP), induced rate of atrial fibrillation, and expression of related indicators of sympathetic nerve activation and remodeling were compared among the three groups. Results ①After the experiment, the body weight of two month administration group and four month administration group were lower than those of control group, and the body weight of four month administration group was lower than that of two month administration group (P ＜ 0.05); the heart rate of two month administration group and four month administration group were faster than those of control group (P ＜ 0.05). ②The LAERP in the two month administration group and four month administration group were shorter than those in the control group, and that in the four month administration group was shorter than that in the two month administration group (P ＜ 0.05). ③The induced rate of atrial fibrillation in the four month administration group was higher than that in the two month administration group and the control group (P ＜ 0.05). ④The level of norepinephrine in the two month administration group and the four month administration group were higher than those in the control group (P ＜ 0.05). ⑤The relative expression of tyrosine hydroxylase (TH) and growth associated proteins-43 (GAP-43) mRNA in the two month administration group and four month administration group were higher than those in the control group (P ＜ 0.05), and the relative expression of GAP-43 mRNA in the four month administration group was higher than that in the two month administration group (P ＜ 0.05). ⑥The relative expression of TH and GAP-43 protein in the two month administration group and four month administration group were higher than those in the control group (P ＜ 0.05), and the relative expression of GAP-43 protein in the four month administration group was higher than that in the two month administration group (P ＜ 0.05). Conclusion Atrial sympathetic nerve is overactivated and remodeled under continuous high level of thyroxine exposure, which may be one of the pathogenesis of hyperthyroidism-induced atrial fibrillation.

Key words： Atrial fibrillation Hyperthyroidism Sympathetic nerve Remodeling

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	ZHENG Jialin1 DAI Hualei1 ZHANG Xinjin1 LI Jianmei2

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ZHENG Jialin1 DAI Hualei1 ZHANG Xinjin1 LI Jianmei2. The study of the pathogenesis of hyperthyroidism-induced atrial fibrillation and atrial sympathetic nerve remodeling[J]. 中国医药导报, 2019, 16(5): 9-13,18.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I5/9

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