D-双功能蛋白在子宫内膜癌组织中的表达及意义

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Abstract Objective To detect the expression level of D-bifunctional protein (DBP) in endometrial cancer tissues and its correlation with the detection results of serum tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125), and to explore the clinical significance of DBP in the diagnosis and treatment of endometrial cancer. Methods From January 2013 to December 2015, 30 cases of patients undergoing endometrial cancer resection in Tangshan Maternal and Child Health Care Hospital (hereinafter referred to as "our hospital") were selected as the experimental group, and 20 cases of normal persons who underwent physical examination during the same period in our hospital were selected as the control group. Chemiluminescence was used to detect the expression levels of serum tumor markers CEA and CA125, and immunohistochemistry was used to detect the expression levels of DBP in endometrial and paracancer tissues, and the integral optical density value (IOD) was measured. Pearson correlation analysis was used to analyze the correlation between DBP and tumor markers CEA and CA125. Results The expression of IOD value of DBP in endometrial carcinoma was higher than that in adjacent tissues, and the difference was statistically significant (P ＜ 0.05). There was a positive linear correlation between DBP and tumor markers CEA (r = 0.837, P < 0.01) and CA125 (r = 0.787, P < 0.01). Conclusion The expression of DBP is increased in patients with endometrial cancer and is closely related to the occurrence and development of endometrial cancer. The combined detection of CEA, CA125 and DBP has important significance for the early diagnosis of endometrial cancer, and provides a new research target for the treatment and prognosis of endometrial cancer.

Key words： Endometrial cancer D-bifunctional protein Carcinoembryonic antigen Carbohydrate antigen 125 Genetic diagnosis

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	LU Xin1 KONG Lingyu2▲

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LU Xin1 KONG Lingyu2▲. Expression and significance of D-bifunctional protein in endometrial carcinoma[J]. 中国医药导报, 2019, 16(4): 161-163,168.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I4/161

[1] Morrison DH，Rahardja D，King E，et al. Tumour biomarker expression relative to age and molecular subtypes of invasive breast cancer [J]. Br J Cancer，2012，107（2）：382-387.
[2] Jiang LL，Miyazawa S，Souri M，et al. Structure of D-3-Hydroxyacyl-CoA Dehydratase/D-3-Hydroxyacyl-CoA Dehydrogenase Bifunctional Protein1 [J]. J Biochem，1997， 121（3）：506-513.
[3] Lu X，Ma P，Shi Y，et al. NF-κB increased expression of 17β-hydroxysteroid dehydrogenase 4 promotes HepG2 proliferation via inactivating estradiol [J]. Mol Cell Endocrinol，2015，401（C）：1-11.
[4] 张菁.联合检测血清CA125、CA125、CA199对子宫内膜癌的诊断价值[J].内蒙古医学杂志，2009，41（5）：547-549.
[5] Dufy MJ，Shering S. CA 153：aprognostic marker in breast cancer [J]. Int Markers，2000，15（4）：330-333.
[6] 郑航，罗荣城.TPS CA2153和CEA联合检测对乳腺癌的诊断[J].第一军医大学学报，2005，25（10）：1293-1298.
[7] 罗丽丽，张易欣，倪惠杰，等.EpCAM和CA125在子宫内膜腺癌及子宫癌前病变患者血清中的表达水平与意义[J].中国妇幼保健，2014，29（5）：484-486.
[8] Zhou X，Wang H，Wang X. Preoperative CA125 and fibrinogen in patients with endometrial cancer：a risk model for predicting lymphovascular space invasion [J]. J Gynecol Oncol，2017，28（2）：e11.
[9] Baser E，Gungor T，Togrul C，et al. Preoperative prediction of poor prognostic parameters and adjuvant treatment in women with pure endometrioid type endometrial cancer：what is the significance of tumor markers？ [J]. Eur J Gynaecol Oncol，2014，35（5）：513-518.
[10] Wang H，Xiao SS，Zeng F，et al. Synchronous primary endometrial and fallopian tube cancers：one case report [J]. Nan Fang Yi Ke Da Xue Xue Bao，2011，31（12）：2093-2094.
[11] Dolscheid-Pommerich RC，Keyver-Paik M，Hecking T，et al. Clinical performance of LOCITM-based tumor marker assays for tumor markers CA-153，CA125，CEA，CA19-9 and AFP in gynecological cancers [J]. Tumour Biol，2017，39（10）：1010428317730246.
[12] 洪锡田，王景萍，张瑞丽.血清CA153、CA125、CEA、SF检测在乳腺癌诊断中的价值[J].中国民康医学，2007， 19（1）：23-24.
[13] Rasiah KK，Gardiner-Garden M，Padilla EJ，et al. HSD17B4 overexpression，an independent biomarker of poor patient outcome in prostate cancer [J]. Mol Cell Endocrinol，2009， 301（1/2）：89-96.
[14] English MA，Kane KF，Cruickshank N，et al. Loss of estrogen inactivation in colonic cancer [J]. J Clin Endocrinol Metab，1999，84（6）：2080-2085.
[15] Mcmichael AJ，Potter JD. Colon cancer and sex[J]. The Lancet，1982，319（8282）：1190-1191.
[16] Nagayoshi Y，Ohba T，Yamamoto H，et al. Characterization of 17beta-hydroxysteroid dehydrogenase type 4 in human ovarian surface epithelial cells [J]. Mol Hum Reprod，2005，11（9）：615-621.
[17] Maleki J，Nourbakhsh M，Shabani M，et al. 17beta-Estradiol Stimulates Generation of Reactive Species Oxygen and Nitric Oxide in Ovarian Adenocarcinoma Cells（OVCAR 3）[J]. Iran J Cancer Prev， 2015，8（3）：e2332.
[18] Moeller G，Adamski J. Multifunctionality of human 17beta-hydroxysteroid dehydrogenases [J]. Mol Cell Endocrinol，2006，248（1/2）：47-55.
[19] Markus M，Husen B，Leenders F，et al. The organelles containing porcine 17 beta-estradiol dehydrogenase are peroxisomes [J]. Eur J Cell Biol，1995，68（3）：263-267.
[20] de Launoit Y，Adamski J. Unique multifunctional HSD17B4 gene product：17beta-hydroxysteroid dehydrogenase 4 and D-3-hydroxyacyl-coenzyme A dehydrogenase/hydratase involved in Zellweger syndrome [J]. J Mol Endocrinol，1999，22（3）：227-240.
[21] Santolla MF，Lappano R，De Marco P，et al. G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17beta-estradiol in cancer cells and cancer-associated fibroblasts [J]. J Biol Chem，2012，287（52）：43234-43245.