尿激酶静脉溶栓与超选择性动脉溶栓治疗急性大脑中动脉脑梗死的效果

Abstract
Figure/Table
References (23)
Related Citation (7)

Download: PDF (851 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the effect of urokinase intravenous thrombolysis and superselective arterial thrombolysis in the treatment of acute middle cerebral artery cerebral infarction. Methods From April 2015 to June 2017, 104 patients with acute middle cerebral artery cerebral infarction admitted to the Second Department of Neurology, the People's Liberation Army Hospital 211, were divided into urokinase intravenous thrombolysis group (n = 52) and superselective arterial thrombolysis group (n = 52) according to different treatment methods. The National Institutes of Health Stroke Scale (NIHSS) score, coagulation function, vascular recanalization rate, satisfaction, and complications were observed and compared between the two groups before and 7 days after thrombolysis. Results There was no significant difference in NIHSS score between the two groups before thrombolysis (P > 0.05). The NIHSS score of the two groups on the 7th day after thrombolysis was lower than that before thrombolysis. The NIHSS score of the superselective arterial thrombolysis group on the 7th day after thrombolysis was lower than that of the urokinase intravenous thrombolysis group (P < 0.05). There was no significant difference in fibrinogen (FIB), prothrombin time (PT) and thrombin time (TT) between the two groups before and 7 days after thrombolysis (P > 0.05). The vascular recanalization rate, total effective rate and patient satisfaction of the superselective arterial thrombolysis group were higher than those of the urokinase intravenous thrombolysis group, and the incidence of complications was lower than that of the urokinase intravenous thrombolysis group, the differences were statistically significant (P < 0.05). Conclusion Superselective arterial thrombolysis can significantly improve the neurological function of patients with acute middle cerebral artery cerebral infarction. The thrombolytic effect is better and the complications are less. It is worthy of clinical application.

Key words： Urokinase intravenous thrombolysis Superselective artery thrombolysis Acute middle cerebral artery cerebral infarction National Institutes of Health Stroke Scale score Coagulation function Vascular recanalization rate

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YU Libo1 WANG Shuai1 JIANG Ying2 GU Jiumei2

Cite this article:

YU Libo1 WANG Shuai1 JIANG Ying2 GU Jiumei2. Effect of urokinase intravenous thrombolysis and superselective artery th-rombolysis on acute middle cerebral artery infarction[J]. 中国医药导报, 2019, 16(4): 100-103,111.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I4/100

[1] 张幼林，郑华，崔颖，等.轻症脑梗死rt-PA静脉溶栓的疗效及安全性观察[J].中国实用神经疾病杂志，2017，20（2）：1-4.
[2] 王玉，李晓强，孔咏梅，等.静脉rt-PA溶栓联合Solitaire支架取栓治疗急性颅内大动脉闭塞的临床观察[J].疑难病杂志，2017，16（5）：461-464.
[3] Chamorro A，Amaro S，Castellanos M，et al. Safety and efficacy of uric acid in patients with acute stroke（URICO-ICTUS）：a randomised，double-blind phase 2b/3 trial [J]. Lancet Neurol，2014，13（5）：453-460.
[4] 赵航.探讨r-tPA静脉溶栓治疗急性脑梗死的疗效[J].航空航天医学杂志，2016，27（4）：474-475.
[5] Justicia C，Salas-Perdomo A，Pérez-de-Puig I，et al. Uric acid is protective after cerebral ischemia/reperfusion in hyperglycemic mice [J]. Transl Stroke Res，2017，8（3）：294-305.
[6] 范琳，黄晶，吴正刚，等.尿酸与缺血性脑卒中rt-PA静脉溶栓预后：前瞻性研究[J].中风与神经疾病杂志，2018， 35（1）：48-51.
[7] Liu X，Liu M，Chen M，et al． Serum uric acid is neuroprotective in Chinese patients with acute ischemic stroke treated with intravenous recombinant tissue plasminogen activator [J]. J Stroke Cerebrovasc Dis，2015，24（5）：1080-1086.
[8] 中华医学会神经病学分会，中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南（2014）[J].中华神经科杂志，2015，48（4）：246-257.
[9] 全国第四届脑血管学术会议.脑卒中患者临床神经功能缺损程度评分标准（1995）[J].中华神经科杂志，1996，29（6）：381-383.
[10] 朱传英，林峰.尿激酶静脉溶栓与超选择性动脉溶栓治疗急性大脑中动脉脑梗死的疗效及对FIB、PT和TT的影响[J].脑与神经疾病杂志，2018，26（4）：221-225.
[11] Pan SM，Liu JF，Liu M，et al. Efficacy and safety of a modified intravenous recombinant tissue plasminogen activator regimen in chinese patients with acute ischemic stroke [J]. J Stroke Cerebrovasc Dis，2013，22（5）：690-693.
[12] 杨伟华.超选择性动脉溶栓治疗急性大脑中动脉脑梗死的疗效和安全性[J].中国实用神经疾病杂志，2017，20（6）：74-76.
[13] Cortijo E，García-Bermejo P，Calleja AI，et al. Intravenous thrombolysis in ischemic stroke with unknown onset using CT perfusion [J]. Acta Neurologica Scandinavica，2014，129（3）：178-183.
[14] 李腾，钟仁佳，孙婧菡，等.超选择性动脉溶栓治疗急性大脑中动脉脑梗死的疗效和安全性评价[J].现代生物医学进展，2017，17（6）：1053-1055，1119.
[15] Lee WI，Mitchell P，Dowling R，et al. Clinical factors are significant predictors of outcome post intra-arterial therapy for acute ischaemic stroke：A review [J]. J Neuroradiol，2013，40（5）：315-325.
[16] 邹蓉，刘朝霞，曲晓宁，等.超选择性动脉溶栓与静脉溶栓治疗急性脑梗死的临床效果对比[J].实用心脑肺血管病杂志，2015，23（8）：47-49，50.
[17] 刘静.超选择性动脉溶栓治疗急性大脑中动脉脑梗死的疗效和安全性研究[J].中国现代医生，2017，55（27）：52-54.
[18] 王占强，徐莉，周利，等.不同方法治疗急性大脑中动脉闭塞致急性脑梗死的疗效观察[J].中国实用神经疾病杂志，2016，19（12）：67-68.
[19] 余小艳，石际俊，姜春黎，等.血尿酸水平与rt-PA静脉溶栓卒中患者预后及脑出血转化的相关性分析[J].中华医学杂志，2015，95（29）：2351-2354.
[20] 杨松柏，侯旭晖，尹健，等.不同尿激酶溶栓方案对肺血栓栓塞症模型犬肺功能及凝血指标的影响[J].临床和实验医学杂志，2018，17（1）：40-44.
[21] 张新斌，肖玲霞，黄晓芸，等.rt-PA与尿激酶静脉溶栓治疗急性脑梗死疗效对比分析[J].中国医药科学，2017， 7（21）：69-71.
[22] Mullen MT，Pisapia JM，Tilwa S，et al. Systematic review of outcome after ischemic stroke due to anterior circulation occlusion treated with intravenous，intra-arterial，or combined intravenous intraarterial thrombolysis [J]. Stroke，2012，43（9）：2350-2355.
[23] Guerrero AT，zaIpelon AC，Vieira SM，et a1. The role of PAF/PAFR signaling in zymosan-induced articular in-nammatory hyperalgesia [J]. Naunyn schmiedebergs Arch Pharmacol，2013，386（1）：51-59.