PD-1/PD-L1在三阴性乳腺癌中的研究进展

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Abstract Immunotherapy is one of the most popular research fields, and has proved to be effective by many clinical research centers in tumor drug trials. Program-med death receptor ligand 1 (PD-L1) is a molecule involved in immunosuppression pathway, and express in more solid tumor cells and the peripheral T lymphocyte significantly on the surface. It can combine with the programmed death receptor 1 (PD-1), inhibit the immune micro-environment around the tumor tissue, promote the deterioration of the tumor cells. Triple-negative breast cancer(TNBC), as a sub-type of breast cancer, is not sensitive to breast cancer treatment, the prognosis and life quality of patients are poor. This paper elaborates the progress in clinical trials of PD-1/PD-L1 expression and related inhibitory drugs in TNBC, and provides new ideas for the treatment of individual patients with TNBC.

Key words： Programmed death receptor 1 Programmed death ligand 1 Triple-negative breast cancer Progress

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	FAN Yu QIAN Zhen SU Qinjun LI Tiantian LIU Bin▲

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FAN Yu QIAN Zhen SU Qinjun LI Tiantian LIU Bin▲. Advances in the study of PD-1/PD-L1 in triple-negative breast cancer[J]. 中国医药导报, 2017, 14(33): 51-54,63.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I33/51

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