胰腺炎外科手术的治疗效果及对患者TNF-α、IL-6水平的影响

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Abstract Objective To investigate the effect of surgical treatment for pancreatitis and its effect on the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Methods Fifty patients with pancreatitis treated in Department of General Surgery, Jiangsu Province Hospital of Chinese Medicine, affiliated to Nanjing University of Chinese Medicine from August 2012 to January 2016 were selected. All the patients underwent surgical treatment. According to the type of operation, they were divided into control group (25 cases) and observation group (25 cases). The control group was treated with laparotomy, the observation group was treated with laparoscopic surgery. Treatment effect was evaluated on the 5th day after operation. The operative time, intraoperative blood loss, total surgical cost, blood amylase recovery time and intestinal function recovery time were recorded and counted. The incidence of incision infection, lung infection, vasculitis, leukopenia in the two groups were recorded and counted. The effect of surgery on the levels of TNF-α, IL-6 were compared. Results The operative time, intraoperative blood loss, total surgery cost, blood amylase recovery time and recovery time of intestinal function in the observation group were all shorter/less than those in the control group (P ＜ 0.05). The levels of TNF-α and IL-6 5 d after operation in the two groups were lower than those before treatment (P ＜ 0.05), and the levels of TNF-α and IL-6 in the observation group were lower than those in the control group (P ＜ 0.05). The incidence of incision infection, lung infection, vasculitis and leucopenia rate in the observation group 5 d after operation were lower than those in the control group (P ＜ 0.05). Conclusion The use of laparoscopic surgery in treating patients with pancreatitis can shorten the time for symptom improvement. The surgical trauma is small, and it can reduce the level of postoperative inflammatory factors and the incidence of postoperative complications. It is worthy of popularization and application.

Key words： Laparoscopic surgery Pancreatitis Laparotomy Inflammatory factors Complications Enzyme-linked immunosorbent assay

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	LI Jiangli GONG Guanwen ZHANG Chuanzhuo ZHANG Yi

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LI Jiangli GONG Guanwen ZHANG Chuanzhuo ZHANG Yi. The effect of surgical treatment for pancreatitis and its influence on the level of TNF-α and IL-6 in patients[J]. 中国医药导报, 2019, 16(4): 88-91.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I4/88

[1] 王军锋，李娜，罗卿.腹腔镜手术治疗重症急性胰腺炎及对TNF-α、IL-6和sIL-2R水平的影响[J].中国内镜杂志，2017，23（11）：74-78.
[2] 何相好，郭霞，何智勇，等.不同麻醉方式对腹部手术患者术后感染与免疫功能及血清IL-6和TNF-α水平的影响研究[J].中华医院感染学杂志，2017，27（5）：1074-1077.
[3] Yuan CH，Wang J，Xiu DR，et al. Meta-analysis of Liver Resection Versus Nonsurgical Treatments for Pancreatic Neuroendocrine Tumors with Liver Metastases [J]. Ann Surg Oncol，2016，23（1）：244-249.
[4] 罗进光，张嘉宁，王智彬，等.参麦注射液与曲美他嗪和左卡尼汀联合治疗急性病毒性心肌炎的临床疗效及对血清TNF-α和IL-6水平的影响[J].中华医院感染学杂志，2017，27（3）：576-579.
[5] 张圣道，雷若庆.重症急性胰腺炎诊治指南[J].中华外科杂志，2007，45（11）：727-729.
[6] 谢伶俐，吴方建，梁斌，等.吡格列酮对合并代谢综合征的非酒精性脂肪性肝病患者血清TNF-α、IL-6的影响及意义[J].中国医院药学杂志，2016，36（12）：1007-1011.
[7] 刁云锋，张士俊，赵万勇，等.血必净注射液对重症肺炎患者血浆IL-6和TNF-α水平的影响[J].中草药，2017， 48（6）：1188-1191.
[8] 陈中建，苟菲，张天锋，等.肺部感染对重症急性胰腺炎患者呼吸功能及外周血炎症因子的影响[J].中华医院感染学杂志，2017，27（9）：2050-2053.
[9] Nipp RD，Zanconato A，Zheng H，et al. Predictors of Early Mortality After Surgical Resection of Pancreatic Adenocarcinoma in the Era of Neoadjuvant Treatment [J]. Pancreas，2017，46（2）：183-189.
[10] 陈先强，姚义，黄鹤光.白细胞介素-10对大鼠重症急性胰腺炎血清肿瘤坏死因子-α及胰腺组织的影响[J].中华肝胆外科杂志，2016，22（8）：562-565.
[11] 平贯芳，熊万成，邓智建.生长抑素与清胰汤联合治疗急性重症胰腺炎的疗效观察[J].中成药，2016，38（10）：2132-2135.
[12] Yasukawa M，Kawaguchi T，Kawai N，et al. Surgical Treatment for Pulmonary Metastasis of Pancreatic Ductal Adenocarcinoma：Study of 12 Cases [J]. Anticancer Res，2017， 37（10）：5573.
[13] 张红松，冯芳，付丽彬，等.不同炎性因子对重症急性胰腺炎的预测价值研究[J].中国全科医学，2017，20（25）：3127-3131.
[14] 王忠琼，琼翼吕，沐瀚夏，等.重症急性胰腺炎患者早期应用微创置管引流的治疗效果评价[J].中国全科医学，2017，20（s1）：84-86.
[15] 罗俊君，胡梅.大黄通便颗粒结合早期肠内营养治疗重症胰腺炎的临床疗效观察[J].中药材，2016，39（7）：1667-1669.
[16] 王敏杰，李慧芳.临床药师参与1例重症急性胰腺炎抗感染治疗病例分析[J].中国医院用药评价与分析，2015， 15（2）：234-236.
[17] Gaetano JN，Singh A，Chapman CG. Mo1035 Characteristics and Outcomes of Acute Biliary Pancreatitis Among Patients With Cirrhosis [J]. Gastroenterology，2015，148（4）:S-1069.
[18] 张国强，冯雪峰，金燕平，等.腹腔镜胆囊切除联合术中与术前内镜十二指肠乳头括约肌切开治疗胆石症[J].中华肝胆外科杂志，2015，21（4）：248-252.
[19] 侯湘德，白剑，谢开汉，等.腹腔镜胆囊切除术治疗急性结石性胆囊炎合并糖尿病59例[J].中国微创外科杂志，2016，16（4）：377-379.
[20] 江宗奇.乌司他丁与奥曲肽联合治疗急性重症胰腺炎的疗效观察[J].中国医院用药评价与分析，2016，16（1）：26-28.