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| Research progress of Wnt signal pathway and male infertility |
| FU Wenting JIANG Huihua ZHONG Xingming ZHOU Bingyi LIU Xiaoyang LIU Xingzhang▲ |
| Key Laboratory of Male Reproduction and Genetics, Guangdong Institute of Family Planning Science and Technology, Guangdong Province, Guangzhou 510060，China |
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Abstract Wnt signaling pathway is a highly conserved signaling pathway, which plays a fundamental role in various human development processes and in maintaining adult tissue homeostasis. The classical Wnt signaling pathway is closely related to the development and differentiation of cells. Wnt signaling pathway plays an important role in maintaining sperm morphology and function in male mammals. The abnormal Wnt signaling pathway is related to male infertility and testicular cancer. This article reviews the latest progress in the role of Wnt signaling pathway in male reproductive system and its relationship with male infertility, in order to further understand the mechanism of Wnt signaling pathway and provide reference for the treatment of male infertility.
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[1] Hernandez Gifford JA. The role of WNT signaling in adult ovarian folliculogenesis [J]. Reproduction，2015，150（4）：R137-R148.
[2] Ferlin A，Foresta C. New genetic markers for male infertility [J]. Curr Opin Obstet Gynecol，2014，26（3）：193-198.
[3] Tiberio P，Lozneanu LL，Angeloni V，et al. Involvement of AF1q/MLLT11 in th progression of ovarian cancer [J]. Oncotarget，2017，8（14）：23 246-23 264.
[4] Plaseska-Karanfilska D，Noveski P，Plaseski T，et al. Genetic causes of male infertility [J]. Balkan J Med Genet，2012，15：31-34.
[5] Weedinj W，Khera M，Lipshultz L. Varicocele repair in patients with nonobstructive azoosperima：a meta-analysis [J]. J Urol，2010，183（6）：2309-2315.
[6] Zhang X，Hao L，Meng L，et al. Digital gene expression tag profiling analysis of the gene expression patterns regulating the early stage of mouse spermatogenesis [J]. PLoS One，2013，8（3）：e58 680.
[7] Chen MW，Yang ST，Chien MH，et al. The STAT3-miR-NA-92-Wnt signaling pathway regulates spheroid fomation an malignant progression in ovarial cancer [J]. Cancer Res，2017，77（8）：1955-1967.
[8] Holstein TW. The evolution of the Wnt pathway [J]. Cold Spring Harb Perspect Biol，2012，4（7）：a007 922.
[9] Wallkamm V，Rahm K，Schmoll J，et al. Regulation of distinct branches of the non-canonical Wnt-signaling network in Xenopus dorsal marginal zone explants [J]. BMC Biol，2016，14：55.
[10] Fodde R， Tomlinson I. Nuclear b-catenin expression and Wnt signalling：in defence of the dogma [J]. J Pathol，2010，221（3）：239-241.
[11] Madan B，Ke Z，Lei ZD，et al. NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition [J]. Oncotarget，2016，7（11）：12 386-12 392.
[12] Ashouri S，Khujin MH，Kazemi M，et al. Effect of teicoplanin on the expression of c-myc and c-fos proto-oncogenes in MCF-7 breast cancer cell line [J]. Adv Biomed Res，2016，5（1）：172-175.
[13] Barker N. The canonical Wnt/beta-catenin signalling pathway [J]. Methods Mol Biol，2008，468：5-15.
[14] Hassanian SM，Ardeshirylajimi A，Dinarvand P，et al. Inorganic polyphosphate promotes cyclin D1 synthesis through activation of mTOR/Wnt/β-catenin signaling in endothelial cells [J]. J Thromb Haemost，2016，14（11）：2261-2273.
[15] Bukowska J，Ziecik AJ，Laguna J，et al. The Importance of the Canonical Wnt Signaling Pathway in the Porcine Endometrial Stromal Stem/Progenitor Cells：Implications for Regeneration [J]. Stem Cells Dev，2015，24（24）：2873-2885.
[16] Yu WZ，Chen XM，Niu WB，et al. Role of Wnt5a in the differentiation of human embryonic stem cells into endometriumlike cells [J] Int J Clin Exp Pathol，2015，8（5）：5478-5484.
[17] Yeh JR， Zhang X， Nagano MC. Wnt5a is a cell-extrinsic factor that supports mouse spermatogonial stem cell-renewal [J]. J Cell Sci，2011，124（14）：2357-2366.
[18] Fan X，Krieg S，Hwang JY，et al. Dynamic regulation of Wnt7a expression in the primate endometrium：implications for postmenstrual regeneration and secretory transformation [J]. Endocrinology，2012，153（3）：1063-1069.
[19] Bernkopf DB，Hadjihannas MV，Behrens J. Negative-feedback regulation of the Wnt pathway by conductin/axin2 involves insensitivity to upstream signalling [J]. J Cell Sci，2015，128（1）：33-39.
[20] Miller C，Degenhardt K，Sassoon DA. Fetal exposure to DES results in deregulation of Wnt7a during uterine morphogenesis [J]. Nat Genet，1998，20（3）：228-230.
[21] Kerr GE， Young JC，Horvay K，et al. Regulated Wnt/Beta-Catenin Signaling Sustains Adult Spermatogenesis in Mice [J]. Biol Reprod，2014，90（1）：3.
[22] Huang N，Wen Y，Guo XJ，et al. A Screen for Genomic Disorders of Infertility Identifies MAST2 Duplications Associated with Nonobstructive Azoospermia in Humans [J]. Biol Reprod，2015，93（3）：61.
[23] Qiu CZ，Wang MZ，Yu WS，et al. Correlation of GOLPH3 gene with Wnt signaling pathway in human colon cancer cells [J]. J Cancer，2016，7（8）：928-934.
[24] Lüdtke TH，Rudat C，Wojahn I，et al. Tbx2 and Tbx3 act downstream of Shh to maintain canonical Wnt signaling during branching morphogenesis of the murine lung [J]. Dev Cell，2016，39（2）：239-253.
[25] Kohn MJ，Kaneko KJ，Depamphilis ML. DkkL1 （Soggy），a Dickkopf family member，localizes to the acrosome during mammalian spermatogenesis [J]. Mol Reprod Dev，2005，71（4）：516-522.
[26] Liu S，Liu YP，Huang ZJ，et al. Wnt/Ryk signaling contributes to neuropathic pain by regulating sensory neuron excitability and spinal synaptic plasticity in rats [J]. Pain，2015，156（12）：2572-2584.
[27] Chang YF，Lee-Chang JS，Harris KY，et al. Role of b-catenin in post-meiotic male germ cell differentiation [J]. PLoS One，2011，6（11）：e28 039.
[28] Li Q，Ishikawa TO，Miyoshi H，et al. A targeted mutation of Nkd1 impairs mouse spermatogenesis [J]. J Biol Chem，2005，280（4）：2831-2839.
[29] Boyer A，Hermo L，Paquet M，et al. Seminiferous tubule degeneration and infertility in mice with sustained activation of WNT/CTNNB1 signaling in sertoli cells [J]. Biol Reprod，2008，79（3）：475-485.
[30] Tanwar PS，Kaneko-Tarui T，Zhang L，et al. Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis [J]. Biol Reprod，2010，82（2）：422-432.
[31] Yang X，Sun J，Xia D，et al. Capn4 Enhances Osteopontin Expression through Activation of the Wnt/β-Catenin Pathway to Promote Epithelial Ovarian Carcinoma Metastasis [J]. Cell Physiol Biochem，2017，42（1）：185-197. |
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