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Research status and progress of immune nutrition in the treatment of digestive tract tumors |
LIU Li WANG Qinglan▲ ZHENG Yongfa |
Department Two of Oncology, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China |
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Abstract This paper reviews the origin and development of immune nutrition, and summarizes the unique anti-tumor characteristics of four common clinical immune nutrients, glutamine, arginine, polyunsaturated fatty acids and microecological immune nutrition in digestive tract tumors. As well as the present immunological nutrition in the clinical use process faces the challenge and to the future prospect. Combined with the literatures of immune nutrition at home and abroad in recent years, this paper provides a reference for the clinical nutrition treatment of patients with digestive tract tumors.
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[1] 崔久嵬,卓文磊,黄岚,等.肿瘤免疫营养治疗指南[J].肿瘤代谢与营养电子杂志,2016,3(4):224-228.
[2] Beisel WR. History of nutritional immunology:introduction and overview [J]. J Nutr,1992,122(3Suppl):591-596.
[3] Wilmore DW,Dudrick SJ. Growth and development of an infant receiving all nutrients exclusively by vein [J]. JAMA,1968,203(10):860-864.
[4] Altman BJ,Stine ZE,Dang CV. From Krebs to clinic:glutamine metabolism to cancer therapy [J]. Nat Rev Cancer,2016,16(10):619-634.
[5] 黄明君,李卡.免疫营养物质对胃肠肿瘤手术患者炎性反应影响的研究进展[J].肠外与肠内营养,2015,22(4):248-250.
[6] Gul K,Muge A,Taner A,et al. Oral glutamine supplementation reduces radiotherapy- induced esophagitis in lung cancer patients [J]. Asian Pac J Cancer Prev,2015,16(1):53-58.
[7] Desideri E,Ciriolo MR. Glutamine Addiction of Cancer Ce-lls [M]. New York:Glutamine in Clinical Nutrition,2015.
[8] Smith B,Schafer XL,Ambeskovic A,et al. Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells [J]. Cell Rep,2016,17(3):821-836.
[9] Saqcena M,Mukhopadhyay S,Hosny C,et al. Blocking an-aplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs [J]. Oncogene,2015,34(20):2672-2680.
[10] Flores ER. Commentary on “Apoptosis,p53,and Tumor Cell Sensitivity to Anticancer Agents” [J]. Cancer Res,2016, 76(23):6763.
[11] Jolfaie NR,Mirzaie S,Ghiasvand R,et al. The effect of glutamine intake on complications of colorectal and colon cancer treatment:A systematic review [J]. J Res Med Sci,2015,20(9):910-918.
[12] Gul K,Muge A,Taner A,et al. Oral Glutamine Supplementation Reduces Radiotherapy- induced Esophagitis in Lung Cancer Patients [J]. Asian Pac J Cancer Prev,2015,16(1):53-58.
[13] 丛明华,宋晨鑫,邹宝华,等.谷氨酰胺、EPA、支链氨基酸对食管癌同步放化疗及胃癌术后辅助化疗患者的影响[J].中华医学杂志,2015,95(10):766-769.
[14] 陶元生.谷氨酰胺肠内营养对老年消化道肿瘤患者术后营养状况及免疫功能的影响[J].海南医学院学报,2017,23(18):2554-2557.
[15] Jeong SM,Hwang S,Park K,et al. Enhanced mitochondrial glutamine anaplerosis suppresses pancreatic cancer growth through autophagy inhibition [J]. Sci Rep,2016, 6:30767.
[16] Hao Y,Samuels Y,Li Q,et al. Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer [J]. Nat Commun,2016,7:11971.
[17] Kim JW,Lee CG,Park YG,et al. Combined analysis of germline polymorphisms of p53,GSTM1,GSTT1,CYP1a1,and CYP2e1 [J]. Cancer,2015,88(9):2082-2091.
[18] Geiger R,Rieckmann JC,Wolf T,et al. L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity [J]. Cell,2016,167(3):829-842.
[19] Hwang JH,Park SJ,Ko WG,et al. Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK/Slug signaling pathway [J]. Am J Cancer Res,2017,7(3):417-432.
[20] Liu ZJ,Li RF,Qi H,et al. Influence of arginine and glutamine on immunologic function and nutritional status of patients with colorectal cancer in perioperative period [J]. J North Sichuan Medical College,2017,32(2):175-177.
[21] Kang K,Shu XL,Zhong JX,et al. Effect of L-arginine on immune function:a meta-analysis [J]. Asia Pac J Clin Nutr,2014,23(3):351-359.
[22] 欧阳暂,姜雅慧,张剑波,等.精氨酸强化的免疫营养支持对胃癌患者术后免疫功能影响的Meta分析[J].循证医学,2017,17(6):350-360.
[23] Sam MR,Ahangar P,Nejati V,et al. Treatment of LS174T colorectal cancer stem-like cells with n-3 PUFAs induces growth suppression through inhibition of survivin expression and induction of caspase-3 activation [J]. Cell Oncol,2016,39(1):69-77.
[24] Ford NA,Rossi EL,Barnett K,et al. Omega-3-Acid Ethyl Esters Block the Protumorigenic Effects of Obesity in Mouse Models of Postmenopausal Basal-like and Claudin-Low Breast Cancer [J]. Cancer Prev Res,2015, 8(9):796.
[25] Mobraten K,Haug TM,Kleiveland CR,et al. Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events,but with different kinetics and intensity in Caco-2 cells [J]. Lipids Health Dis,2013,12(1):101.
[26] Sam MR,Ahangar P,Nejati V,et al. Treatment of LS174T colorectal cancer stem-like cells with n-3 PUFAs induces growth suppression through inhibition of survivin expression and induction of caspase-3 activation [J]. Cell Oncol,2016,39(1):69-77.
[27] Slagsvold JE,Pettersen CHH,Storvold GL,et al. DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells [J]. Nutr Cancer,2010,62(5):611-621.
[28] 马家驰,马云涛,郭天康,等.多不饱和脂肪酸ω-3和ω-6影响胃癌新生血管的机制[J].中华胃肠外科杂志,2017,20(1):84-89.
[29] Stanislaw K. Omega-3 Fatty Acids in Modern Parenteral Nutrition:A Review of the Current Evidence [J]. J Clin Med,2016,5(3):34.
[30] Juliana DAPS,Maria EDSF,Waitzberg DL. Omega-3 supplements for patients in chemotherapy and/or radiotherapy:A systematic review [J]. Clin Nutr,2015,34(3):359-366.
[31] 戴安友.双歧三联活菌胶囊对结直肠癌术后肠道菌群及肠黏膜通透性的影响[J].中国微生态学杂志,2016,28(4):425-428.
[32] 侯安存.乳糖不耐受的诊治进展[J].临床和实验医学杂志,2017,16(2):204-207.
[33] Owaga EE,Elbakkoush A,Masuku SKS,et al. Antiallergic Effects of Probiotic Lactobacilli-Cellular and Molecular Mechanisms [J]. J Microbiol Res,2014,4(2):92-97.
[34] 杨斐斐.肿瘤微环境对NK细胞功能调节的研究进展[J].中国肿瘤生物治疗杂志,2016,23(4):555-559.
[35] 李诗杰,栗芳军.肠内微生态免疫营养对创伤后大鼠肠道免疫功能及损伤修复信号通路Hedgehog蛋白表达的影响[J].中华实验外科杂志,2017,34(3):414-416.
[36] Shao F,Yang D. Impact of microbial immune enteral nutrition on postoperative insulin resistance and infectious complication of patients with abdominal infection [J]. Zhonghua Wei Chang Wai Ke Za Zhi,2014,17(7):676-679.
[37] Cerantola Y,Hübner M,Grass F,et al. Immunonutrition in gastrointestinal surgery [J]. Br J Surg,2011,98(1):37-48.
[38] Klek S,Sierzega M,Szybinski P,et al. The immunomodulating enteral nutrition in malnourished surgical patients — a prospective,randomized,double-blind clinical trial [J]. Clin Nutr,2011,30(3):282-288.
[39] 郭玉文,曹婧然,何立杰,等.添加ω-3多不饱和脂肪酸的营养支持对消化系统恶性肿瘤患者免疫与营养状况作用的Meta分析[J].中华临床营养杂志,2015,23(2):95-102. |
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