飞扬肠胃炎胶囊及其主要成分的体外抗菌作用

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Abstract Objective To explore the in vitro antimicrobial activity of Feiyang Changweiyan Capsules and its main components against common bacteria, and to explore the sensitive strains and main antimicrobial components of Feiyang Changweiyan Capsules. Methods Minimum inhibitory concentration (MIC) of Feiyang Changweiyan Capsules, drug-deficient drugs, gallic acid, ellagic acid and syringin were determined by multiple dilution method. Results Feiyang Changweiyan Capsules had the most significant inhibitory effect on Staphylococcus aureus with MIC value of 1.6 mg/mL, it had significant inhibitory effect on Shigella flexneri and Salmonella enteritidis with MIC value of 3.1 mg/mL, and it had significant inhibitory effect on Escherichia coli, Pseudomonas aeruginosa, Escherichia coli (enterotoxin producing strain), Salmonella typhimurium and Salmonella typhimurium with MIC value of 6.3 mg/mL. The MIC value was 50.0 mg/mL for Klebsiella pneumoniae, almost no inhibition for Candida albicans, MIC value was more than 100.0 mg/mL; Feiyang Changweiyan Capsules showed strong inhibition for clinical bacteria including Escherichia coli, Salmonella typhi, Salmonella enteritidis, Shigella flexneri and Proteus vulgaris, MIC values were 6.3, 6.3, 3.1, 3.1 and 12.5 mg/mL, respectively. Conclusion Feiyang Changweiyan Capsules and its main components, gallic acid, ellagic acid and syringin, have strong antibacterial activity. The sensitive strains are Staphylococcus aureus, Shigella flexneri, Salmonella enteritidis, Escherichia coli, Pseudomonas aeruginosa, Escherichia coli (enterotoxin-producing strains), Salmonella typhimurium, Salmonella typhimurium and Proteus vulgaris. Euphorbia hirta L., Polygonum chinense L. and Ilex rotunda thunb. all have certain antibacterial activity, among which the antimicrobial effect of Ilex rotunda thunb. is slightly better than that of other two traditional Chinese medicines, and the main component of the antibacterial activity of Ilex rotunda thunb may be syringin.

Key words： Feiyang Changweiyan Capsules Minimum inhibitory concentration Antibacterial activity

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	LI Yao1 XU Lu1 XIE Yanhua1 SHI Meng2 WANG Siwang1 YANG Qian1

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LI Yao1 XU Lu1 XIE Yanhua1 SHI Meng2 WANG Siwang1 YANG Qian1. Study of antibacterial of Feiyang Changweiyan Capsules and its main components in vitro[J]. 中国医药导报, 2019, 16(4): 26-29.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I4/26

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