|
|
|
| Research progress of animal models of intracranial aneurysms |
| LI Li1* WU Xuejia2* FU Hao1 WANG Zhihong1 CHEN Dong3 SUN Li1▲ ZHANG Fang4▲ |
1.Department of Neurological Intensive Care Medicine, Affiliated Hospital of Logistics College of PAP, Tianjin 300162, China;
2.Department of Pharmacy, the New Eco City Hospital of Medical University of Tianjin, Tianjin 300467, China;
3.Health Team of Training Base, Liaoning PAP Crops, Liaoning Province, Shenyang 110034, China;
4.The Sixth Department of neurosurgery, Affiliated Hospital of Logistics College of PAP, Tianjin 300162, China |
|
|
|
|
Abstract Intracranial aneurysm (IA) is a tumor like process caused by pathological and localized dilatation of intracranial arteries, once ruptured, it can result in subarachnoid hemorrhage and cause serious consequences. At present, the pathogenesis of IA has yet to be clarified, which result in that onlypatients with high risk of rupture can be treated. Many IA patients have to bear the risk of IA rupture at any time. Therefore, clarifying the mechanism of IA and developing preventive and therapeutic drugsis the key to solve the above problems. Because of the difficulty of obtaining human tissue, IA animal model has become the main research approach. This article will review the progress of IA animal model construction methods, pathological changes and drug treatment, in order to provide reference for further research.
|
|
|
|
|
|
[1] Ravindra VM，de Havenon A，Gooldy TC，et al. Validation of the unruptured intracranial aneurysm treatment score：comparison with real-world cerebrovascular practice [J]. J Neurosurg，2017（10）：1-7.
[2] Czorlich P，Sauvigny T，Ricklefs F，et al. Impact of dexamethasone in patients with aneurysmal subarachnoid haemorrhage [J]. Eur J Neurol，2017，44（2）：1021-1029.
[3] Shimizu K，Imamura H，Mineharu Y，et al. Endovascular treatment of unruptured paraclinoid aneurysms：single-center experience with 400 cases and literature review [J]. AJNR Am J Neuroradiol，2016，37（4）：679-685.
[4] Raymond J，Venne D，Allas S，et al. Healing mechanisms in experimental aneurysms. I. Vascular smooth muscle cells and neointimaformation [J]. J Neuroradiol，1999，26（1）：7-20.
[5] 李浩，马勃，李志强，等.犬动脉瘤动物模型的血流动力学分析[J].天津医药，2015，（10）：1133-1136，1221.
[6] Hashimoto N，Handa H，Hazama F. Experimentally induced cerebral aneurysms in rats [J]. Surg Neurol，1978，10（1）：3-8.
[7] Hashimoto N，Handa H，Hazama F. Experimentally induced cerebral aneurysms in rats：part Ⅱ [J]. Surg Neurol，1979，11（3）：243-246.
[8] Eldawoody H，Shimizu H，Kimura N，et al. Simplified experimental cerebral aneurysm model in rats：comprehensive evaluation of induced aneurysms and arterial changes in the circle of Willis [J]. Brain Res，2009，1300：159-168.
[9] Morimoto M，Miyamoto S，Mizoguchi A，et al. Mouse model of cerebral aneurysm：experimental induction by renal hypertension and local hemodynamic changes [J]. Stroke，2002，33（7）：1911-1915.
[10] Sawyer DM，Pace LA，Pascale CL，et al. Lymphocytes influence intracranial aneurysm formation and rupture：role of extracellular matrix remodeling and phenotypic modulation of vascular smooth muscle cells [J]. J Neuroinflammation，2016，13（1）：185.
[11] Aoki T，Kataoka H，Ishibashi R，et al. Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formation [J]. Stroke，2009，40（3）：942-951.
[12] Gao L，Hoi Y，Swartz DD，et al. Nascent aneurysm formation at the basilar terminus induced by hemodynamics [J]. Stroke，2008，39（7）：2085-2090.
[13] Hashimoto N，Kim C，Kikuchi H，et al. Experimental induction of cerebral aneurysms in monkeys [J]. J Neurosurg，1987，67（6）：903-905.
[14] Aoki T，Fr?觟sen J，Fukuda M，et al. Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms [J]. Sci Signal，2017， 10（2）：465-474.
[15] Albrekkan FM，Bachir S，Jumaa MA，et al. Is there a genetic correlation between multiple sclerosis and cerebral aneurysms？[J]. World Neurosurg，2016，95：624.e1-624.e4.
[16] Chyatte D，Bruno G，Desai S，et al. Inflammation and intracranial aneurysms [J]. Neurosurgery，1999，45（5）：1137-1146.
[17] 高冉，任梦，李瑶，等.腹主动脉瘤炎症机制的研究进展[J].生理科学进展，2016，47（2）：88-92.
[18] Tanaka T，Moriyama T，Kawamura Y，et al. Puerarin suppresses macrophage activation via antioxidant mechanisms in a CaPO4-induced mouse model of aneurysm [J]. J Nutr Sci Vitaminol （Tokyo），2016，62（6）：425-431.
[19] Fennell VS，Kalani MY，Atwal G，et al. Biology of saccular cerebral aneurysms：a review of current understanding and future directions [J]. Front Surg，2016，32（3）：43-51.
[20] Aoki T，Yamamoto K，Fukuda M，et al. Sustained expression of MCP-1 by low wall shear stress loading concomitant with turbulent flow on endothelial cells of intracranial aneurysm [J]. Acta Neuropathol Commun，2016，4（1）：48-59.
[21] Liaw N，Fox JM，Siddiqui AH，et al. Endothelial nitric oxide synthase and superoxide mediate hemodynamic initiation of intracranial aneurysms [J]. PLoS One，2014，9（7）：e101721.
[22] Aoki T，Nishimura M. Targeting chronic inflammation in cerebral aneurysms：focusing on NF-kappa B as a putative target of medical therapy [J]. Expert OpinTher Targets，2010，14（3）：265-273.
[23] Kimura N，Shimizu H，Eldawoody H，et al. Effect of olmesartan and pravastatin on experimental cerebral aneurysms in rats [J]. Brain Res，2010，1322：144-152.
[24] Aoki T，Kataoka H，Ishibashi R，et al. Pitavastatin suppresses formation and progression of cerebral aneurysms through inhibition of the nuclear factor kappa B pathway [J]. Neurosurgery，2009，64（2）：357-365.
[25] 张婷，闫海洋，陈孝储，等.辛伐他汀对颅内动脉瘤大鼠端粒长度、端粒酶反转录酶及端粒重复序列结合因子2基因表达的影响[J].广西医学，2017，39（8）：1195-1197， 1202. |
|
|
|
