脑18F-FDG PET/CT显像对脑癫痫灶的定位及定侧诊断价值

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Abstract Objective To explore the value of fludeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET/CT) in the accurate localization and lateralization of brain epileptogenic focus. Methods From June 2011 to July 2013, 69 patients with medically intractable epilepsy from the General Hospital of Northern Theater Command were selected. 18F-FDG interictal PET/CT, magnetic resonance imaging (MRI), electroencephalo gram (EEG) were performed in those patients and the results were compared with the electroenephalogram monitoring during operations and the pathological tests. Results Among 69 cases of epileptic focus resection, accuracy rate of localization and lateralization of epileptogenic focus by interictal 18F-FDG PET/CT were 62.3% (43/69) and 78.3% (54/69) respectively. Among 43 case of PET/CT localization of simple temporal lobe lesions, the intraoperative electroencephalogram monitoring and surgical pathology confirmed the same localization in 36 cases and the same lateralization in 37 cases, with an accuracy rate of 83.7% (36/43) and an accuracy rate of 86.0% (37/43), which were higher than those in non-temporal lobe lesions [26.9% (7/26), 65.4% (17/26)], the differences were statistically significant (P < 0.05). The lateral accuracy [78.3% (54/69)] of PET/CT for brain epilepsy was significantly higher than that in the location [62.3% (43/69)], the difference was statistically significant (P < 0.05). Accuracy rate of localization of epileptogenic focus in 69 patients by MRI was 42.0% (29/69), accuracy rate of localization of epileptogenic focus in 69 patients by EEG were 44.9% (31/69). PET/CT had higher accuracy rate of localization than MRI and EEG (χ2 = 5.692, 4.196, all P < 0.05). Conclusion Interical 18F-FDG PET/CT possesses higher value than routine examinations such as MRI and EEG in the localization of epileptogenic focus, especially in temporal lobe localization focus.

Key words： Epilepsy 18F-deoxyglucose Positron emission tomography-computed tomography Magnetic resonance imaging Electroencephalogram

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	HAO Shanhu WU Xiaodan WANG Zhiguo ZHAN Ying ZHANG Guoxu▲

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HAO Shanhu WU Xiaodan WANG Zhiguo ZHAN Ying ZHANG Guoxu▲. The diagnostic value of brain 18F-FDG PET/CT in the localization and lateralization of brain epileptogenic focus[J]. 中国医药导报, 2018, 15(34): 149-152.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I34/149

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