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| Efficacy of free-frying Chinese medicine granules as replacement of Chinese herbal medicine in treating hypertension：a Meta analysis |
| WANG Xiaoli1 ZHANG Huiling2 LI Xuejing1 LIU Yang1 LIU Guoqiang1 |
1.Department of Pharmacy, the Third Hospital of Hebei Medical University, Hebei Province, Shijiazhuang 050051, China;
2.Department of Traditional Chinese Medicine, the Third Hospital of Hebei Medical University, Hebei Province, Shijiazhuang 050051, China |
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Abstract Objective To systematically review the efficacy of free-frying Chinese medicine granules as replacement of Chinese herbal medicine in treating hypertension, and to provide the evidence for clinical treatment and the selection of therapy. Methods A systematic search by online databases was performed, including CNKI, WanFang, VIP and PubMed, searching period from the inception to December 3rd, 2017. Randomized controlled trials (RCTs) of free-frying Chinese medicine granules vs. Chinese herbal medicine were collected. According to the Cochrane Handbook, data of the articles conforming to inclusion criteria was extracted and the quality of the articles was evaluated, The meta analysis was performed via RevMan 5.2 software. Results A total of 8 trails were enrolled, which included 1433 cases. Meta analysis results showed that there was no significant difference in efficiency, blood pressure target achievement ratio and TCM symptom score between the treatment of free-frying Chinese medicine granules and Chinese herbal medicine (P ＞ 0.05). Conclusion There is no significant difference between and Chinese herbal medicine in the treating efficacy of hypertension. In the selection of clinical therapy, the minimum cost method in pharmacoeconomics can be the reference for selection, and the treating plan with the minimum cost advantage is the optimal one.
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