miRNA let-7对疾病调控机制的研究进展

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Abstract MicroRNA (miRNA) is a highly conserved single-stranded small molecule RNA, which can regulate the growth, development, differentiation and apoptosis of histocytes. The let-7 miRNA family is currently the most widely studied family of miRNAs. Let-7 can be stably present in human peripheral blood and body fluids, and its expression and maintenance of equilibrium state are achieved by the relevant effects of regulatory factors. Abnormalities in these regulatory pathways lead to abnormal expression of the let-7 family, which leads to the development of tumors, hypertension, epilepsy, and cardiovascular diseases. Therefore, monitoring the expression level of let-7 can prevent and treat diseases associated with it. This review focuses on the research progress of miRNA let-7 on the regulation of these diseases.

Key words： MicroRNA let-7 Mechanism Gene expression Research progress

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	Articles by authors
	WANG Tingting1
	2 WANG Guixiang1
	2 ZHANG Junhui2 LIU Aiju2

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WANG Tingting1,2 WANG Guixiang1,2 ZHANG Junhui2 LIU Aiju2. Research progress on the regulation mechanism of miRNA let-7 on diseases[J]. 中国医药导报, 2018, 15(34): 53-56.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I34/53

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