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| Advances in the study of function and clinical application of exosomes |
| WEI Xiaojing1,2 HU Xiao1,2 |
1.State Key Laboratory of Experimental Hematology, Hematology and Blood Diseases Hospital & Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;
2.Department of Stem Cell and Regenerative Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China |
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Abstract Exosomes are membranous vesicles secreted by cells, which are important mediators for cell communication and participate in the transmission of biological signals between cells. There are five recognized and more commonly used methods of extracting exosomes. The breakthrough of exosomes in clinical research mainly reflects on that exosomes are involved in the development of tumor diseases, nucleic acids or proteins in exosomes can be used as molecular markers of diseases, and exosomes can be used as drug carriers for targeted therapy. The function of exosomes in diseases gives them an advantage in clinical application.This review focuses on the discovery of exosomes, the advantages and disadvantages of exosomes extraction methods and the research progress of exosomes function in
clinical diseases.
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