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| Discussion on the immunological strategies of traditional Chinese medicine for ulcerative colitis based on the theory of “spleen acting as the defense for host” |
| ZHANG Wenji WANG Zhibin CHEN Xinran LI Junxiang YUAN Yali XING Yunqi WANG Muyuan MAO Tangyou |
| Department of Gastroenterology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China |
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Abstract The theory of “spleen acting as the defense for host” believes that the spleen is the source of qi and blood biochemistry, transforming defensive qi, which can resist external evil and protect the body, which is mainly related to the physiological functions of “spleen governing transportation and transformation”, “spleen governing ascending and clearing”. The abnormal physiological function of the spleen is manifested by “spleen losing its duty as the defense”, and all diseases are born. In the development of ulcerative colitis, the breakdown of intestinal mucosal immune barrier plays a key role, and the disturbance of immune cell balance leads to inflammatory damage. It can be seen that the function of immune cells is closely related to the distribution and movement of defensive qi, and the mechanism of intestinal mucosal immune barrier is coupled with the connotation of the theory of “spleen acting as the defense for host”. This paper traces the theoretical origin of “spleen acting as the defense for host”, and combines with the immunological mechanism in modern medicine to explore the new idea of traditional Chinese medicine in the treatment of ulcerative colitis, which is helpful for traditional Chinese medicine to play a greater role in the immunotherapy of ulcerative colitis.
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