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| Research progress on anti-breast cancer effect and mechanism of Jado-mycin and its derivatives |
| MA Lanjing TAN Yuanjun ZHU Zhibo ZHANG Baihong |
| Department of Oncology, the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Gansu Province, Lanzhou 730050, China |
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Abstract Jadomycin and its derivatives are a new group of anthracycline antibiotics isolated from Streptomyces venezuelans, and have been receiving increasing attention because of their cytotoxicity to a variety of cancers, especially breast cancer. This article reviews the research progress of Jadomycin and its derivatives in relation to breast cancer. This review is divided into two parts, the first summaries the anti-breast cancer effect of Jadomycin and its derivatives; the second provides an overview of anti-breast cancer mechanisms of Jadomycin and its derivatives, including induced apoptosis, copper dependent reactive oxygen species generation, topoisomerase inhibition, and aurora kinase B inhibition, etc., which provided an overview of a potential new chemotherapy drug for clinicians.
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