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| Therapeutic role of caspase3 in the non-apoptotic progression of ovarian cancer |
| ZHOU Juanhong1 CHEN Fan1 QIN Tiansheng2 |
1.The First School of Clinical Medicine, Gansu University of Chinese Medicine, Gansu Province, Lanzhou 730000, China;
2.Department of Obstetrics and Gynecology, Gansu Provincial People’s Hospital, Gansu Province, Lanzhou 730000, China |
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Abstract Ovarian cancer is often diagnosed at an advanced stage due to the lack of specific signs and symptoms. In recent years, the emergence of chemoradiotherapy resistance in ovarian cancer leads to high mortality of patients. The study of non-apoptotic procedures in ovarian cancer is essential to improve the survival rate of ovarian cancer. Caspase3 plays an important role in the non-apoptotic regulation of ovarian cancer, and is a major mediator of various anti-cancer therapies in ovarian cancer, such as cytotoxic drugs, radiotherapy, chemotherapy, and immunotherapy, etc. Exploring the role and value of caspase3-mediated non-apoptotic procedures in the treatment of ovarian cancer is important for improving the survival rate of patients. This article reviews the recent research progress of caspase3 in the treatment of ovarian cancer, in order to provide directions for the clinical treatment of ovarian cancer.
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