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| Research progress of circularRNA regulating microRNA axis in allergic rhinitis |
| YAN Min1 NIU Ruibing2 DUAN Baosheng2 |
1.Ordos School of Clinical Medical, Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Ordos 017000, China;
2.Department of Laboratory, Ordos Central Hospital, Inner Mongolia Autonomous Region, Ordos 017000, China |
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Abstract Circular RNA are novel, stable non-coding RNA with gene expression and regulation functions. In recent years, it has been found that the abnormal expression of circularRNA is closely related to the pathogenesis of allergic rhinitis. CircularRNA regulate gene expression by binding to microRNA and affect immune response of allergic rhinitis. This article reviews the current status and progress of the research on regulating the expression of innate immune cells, adaptive immune response, transcription factors, and inflammatory factors by regulating the microRNA axis, and then regulating the production of inflammatory mediators in allergic rhinitis, in order to provide new ideas for the future treatment of allergic rhinitis.
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