中国医药导报
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中国医药导报  2023, Vol. 20 Issue (32): 17-21    DOI: 10.20047/j.issn1673-7210.2023.32.03
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Expression and clinical significance of minichromosome maintenance protein 8 in glioma
ZHOU Chengying1 ZHAO Benhuo2 BAO Lei1 HUA Fang1 YANG Xinxin1
1.Department of Neurology, the Affiliated Hospital of Xuzhou Medical University, Jiangsu Province, Xuzhou 221000, China;
2.Department of Digestive, the Affiliated Hospital of Yangzhou University, Jiangsu Province, Yangzhou 225102, China
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Abstract  Objective To analyze the clinical significance and expression of minichromosome maintenance protein 8 (MCM8) in glioma tissues. Methods MRNA data and the differential expression of MCM8 was extracted and analyzed from 17 glioma and four para-cancerous tissues involved in GSE19728, 156 glioma and five para-cancerous tissues involved in TCGA. China Glioma Genome Atlas analyzed the expressions of MCM8 in various pathological types of gliomas and para-cancerous tissues and the effects of MCM8 on the prognosis of glioma. Enrichment analysis of MCM8 co-expression genes in glioma was performed by DAVID. Interaction molecules of MCM8 were analyzed by STRING and PINA. Correlations between MCM8 expression and the immune infiltrations in the microenvironment of glioma were explored by TISIDB database. Results MCM8 expression in glioma was higher than para-cancerous tissues, the difference was statistically significant (P<0.05). Expressions of MCM8 in gliomas of World Health Organization(WHO) grade Ⅲ and Ⅳ were higher than grade Ⅱ, the differences were highly statistically significant (P<0.01). The survival rates of glioma patients with high MCM8 expression was lower than those with low expression, the differences were statistically significant (P<0.05). MCM8 was involved in the regulation of intracellular DNA replication, response to damage stimulus and other processes. MCM8 was closely related to the members of the cell division control protein and DNA polymerase families. MCM8 expression level in glioma was negatively related to the infiltrating levels of activated T cell, B cell, natural killer cell, dendritic cell and macrophagocytes in the tumor microenvironment (r<0, P<0.05). Conclusion MCM8 is overexpressed in glioma and closely correlated with the progression and prognosis of glioma.
Key wordsMinichromosome maintenance protein 8      Glioma      Bioinformatics     
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ZHOU Chengying1 ZHAO Benhuo2 BAO Lei1 HUA Fang1 YANG Xinxin1
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ZHOU Chengying1 ZHAO Benhuo2 BAO Lei1 HUA Fang1 YANG Xinxin1. Expression and clinical significance of minichromosome maintenance protein 8 in glioma[J]. 中国医药导报, 2023, 20(32): 17-21.
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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.32.03     OR     https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I32/17
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